148003-99-0

Basic information

• Product Name: benzyl (3RS)-3-dimethyl(phenyl)silyl-3-phenylpropanoate
• Synonyms: benzyl (3RS)-3-dimethyl(phenyl)silyl-3-phenylpropanoate
• CAS NO: 148003-99-0
• Molecular Weight: 374.555
• Mol File: 148003-99-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl (3RS)-3-dimethyl(phenyl)silyl-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (3RS)-3-dimethyl(phenyl)silyl-3-phenylpropanoate(148003-99-0)
• EPA Substance Registry System: benzyl (3RS)-3-dimethyl(phenyl)silyl-3-phenylpropanoate(148003-99-0)

Safety Data

• Hazardous Substances Data: 148003-99-0(Hazardous Substances Data)

Upstream product

• 103-41-3 (E)-cinnamic acid benzyl ester 
• 3839-31-4 dimethyl(phenyl)silyllithium 
• 100-51-6 benzyl alcohol 
• 103-41-3 benzy cinnamate 

Downstream Products

• 138235-01-5 3-phenyl-3-dimethyl(phenyl)silylpropanoic acid 
• 164203-14-9 (3S)-3-dimethyl(phenyl)silyl-3-phenylpropanoic acid 
• 153221-16-0 (R)-3-(dimethylphenylsilyl)-3-(phenyl)propanoic acid 
• 97946-09-3 (+/-)-(E)-1-(dimethylphenylsilyl)-1-phenyl-2-butene 
• 97946-11-7 (+/-)-(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-butene 
• 144452-46-0 β-Dimethylphenylsilyl-β-phenyl propanoyl chloride 
• 144452-46-0 3-(Dimethyl-phenyl-silanyl)-3-phenyl-propionyl chloride 
• 2768-42-5 (R)-3-phenyl-3-hydroxypropionic acid 

Relevant articles and documents

Diastereoselectivity in the Preparation of β-Silyl Esters from αβ-Unsaturated Esters and Amides Attachhed to Chiral Auxiliaries

The conjugate addition of the phenyldimethylsilyl-cuprate reagent to cinnamate and crotonate esters and amides 1 of various known chiral auxiliaries, a-e, is diastereoselective.The sense of diastereoselectivity of silyl-cuprate addition to the esters 1b-d, 8 and 9 is different from established precedent based on carbon-cuprates, but is normal for silyl-cuprate addition to the amide 1a, the imines 1e and 21, and the oxazolidine 6.The chiral auxiliary e gives the best results of those tested, and the silicon-containing group can be removed from the chiral auxiliary using alkoxide ion in aprotic media, making available β-silyl esters 27-29 of high enantiomeric excess, with recovery of the chiral auxiliary 30.

Diastereoselective Aldol Reactions of β-Silylenolates: A New Regiocontrolled Synthesis of Allylsilanes

Allylsilanes are prepared stereospecifically trans (10) or cis (12) and with complete regiocontrol by decarboxylative elimination of the β-hydroxy acids (9).