150109-61-8

Basic information

• Product Name: 1-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(4-trifluoromethyl-benzyloxy)-tetrahydro-furan-2-yl]-5-fluoro-1H-pyrimidine-2,4-dione
• CAS NO: 150109-61-8
• Molecular Weight: 518.581
• Mol File: 150109-61-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(4-trifluoromethyl-benzyloxy)-tetrahydro-furan-2-yl]-5-fluoro-1H-pyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(4-trifluoromethyl-benzyloxy)-tetrahydro-furan-2-yl]-5-fluoro-1H-pyrimidine-2,4-dione(150109-61-8)
• EPA Substance Registry System: 1-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(4-trifluoromethyl-benzyloxy)-tetrahydro-furan-2-yl]-5-fluoro-1H-pyrimidine-2,4-dione(150109-61-8)

Safety Data

• Hazardous Substances Data: 150109-61-8(Hazardous Substances Data)

Upstream product

• 50-91-9 5-Fluoro-2'-deoxyuridine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 129816-30-4 5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-fluorouridine 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 179744-34-4 (S)-2-tert-Butoxycarbonylamino-3-methyl-butyric acid 5-fluoro-3-[(2R,4S,5R)-5-hydroxymethyl-4-(4-trifluoromethyl-benzyloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 150109-62-9 5-Fluoro-1-[(2R,4S,5R)-5-hydroxymethyl-4-(4-trifluoromethyl-benzyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Synthesis and biological activity of O-alkyl-3-N-aminoacyloxymethyl-5- fluoro-2'-deoxyuridine derivatives

In an attempt to improve the effectiveness of action of 5-fluoro-2'- deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O- p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.