151139-88-7

Basic information

• Product Name: 4-DIMETHYL-L-GLUTAMIC ACID
• Synonyms: 4,4-DiMethyl-L-glutaMic Acid
• CAS NO: 151139-88-7
• Molecular Formula: C7H13NO4
• Molecular Weight: 175.18
• Product Categories: Heterocyclic Compounds;Chiral Reagents;Neurochemicals;Neurochemicals, Chiral Reagents
• Mol File: 151139-88-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 165-167°C
• Boiling Point: 329.896oC at 760 mmHg
• Flash Point: 153.316oC
• Appearance: /
• Density: 1.275g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Water (Slightly)
• CAS DataBase Reference: 4-DIMETHYL-L-GLUTAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIMETHYL-L-GLUTAMIC ACID(151139-88-7)
• EPA Substance Registry System: 4-DIMETHYL-L-GLUTAMIC ACID(151139-88-7)

Safety Data

• Hazardous Substances Data: 151139-88-7(Hazardous Substances Data)

Usage

Chemical Properties

White

Uses

Different sources of media describe the Uses of 151139-88-7 differently. You can refer to the following data:
1. A glutamate analog
2. A glutamate analog.

InChI:InChI=1/C7H13NO4/c1-7(2,6(11)12)3-4(8)5(9)10/h4H,3,8H2,1-2H3,(H,9,10)(H,11,12)/t4-/m0/s1

Upstream product

• 96544-51-3 2-oxo-4,4-dimethylglutaric acid 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 374633-13-3 dimethyl 2-benzoyl-4,4-dimethylglutarate 
• 374633-14-4 dimethyl 2-diazo-4,4-dimethylglutarate 
• 116418-37-2 dimethyl 2-oxo-4,4-dimethylglutarate 
• 13051-32-6 dimethyl 2,2-dimethylglutarate 
• 681-57-2 2,2-dimethylglutaric acid 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 
• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 158392-80-4 1-tert-butyl 2-ethyl (2S)4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate 
• 158392-74-6 O₁-tert-butyl O₂-methyl (2S)-4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate 

Relevant articles and documents

Chemoenzymatic synthesis of glutamic acid analogues: Substrate specificity and synthetic applications of branched chain aminotransferase from Escherichia coli

(Chemical Equation Presented) A new route to α-keto acids is described, based on the ozonolysis of enol acetates obtained from α-substituted β-keto esters. Escherichia coli branched chain aminotransferase (BCAT) activity toward a variety of substituted 2-oxoglutaric acids was demonstrated analytically. BCAT was shown to have a broad substrate spectrum, complementary to that of aspartate aminotransferase, and to offer access to a variety of glutamic acid analogues. The usefulness of BCAT was demonstrated through the synthesis of several 3- and 4-substituted derivatives.

Synthesis of 4,4-Disubstituted L-Glutamic Acids by Enzymatic Transamination

The syntheses of optically pure 4,4-dimethyl-L-glutamic acid as well as (2S,4R)- and (2S,4S)-4-hydroxy-4-methylglutamic acids have been achieved by transamination of the corresponding 2-oxo-4,4-dimethyl- and rac-2-oxo-4-hydroxy-4-methylglutaric acids using glutamic oxalacetic transaminase (GOT).