15180-03-7 Usage
Description
Alcuronium Chloride, also known as Alloferin, is a neuromuscular blocking agent derived from the pharmaceutical industry. It possesses ganglion blocking activity and is known for its ability to bind to muscarinic M2 receptors. This characteristic makes it a promising candidate for various medical applications.
Uses
Used in Pharmaceutical Industry:
Alcuronium Chloride is used as a neuromuscular blocking agent for its ability to bind to muscarinic M2 receptors, which is particularly useful in medical procedures that require muscle relaxation. Its ganglion blocking activity also contributes to its effectiveness in this application.
Additionally, Alcuronium Chloride is used as an adjunct in various medical treatments where muscle relaxation is necessary, such as during surgeries or in the management of certain medical conditions that involve muscle spasms or involuntary muscle contractions. Its brand name, Alloferin, is associated with Hoffmann-LaRoche-International, indicating its commercial availability and widespread use in the healthcare sector.
Originator
Alloferin, Roche ,UK ,1966
Manufacturing Process
31 g of diallylnortoxiferine diiodide are suspended in 1 liter of water and
shaken with 1,100 ml of Amberlite IRA-400 [chloride ion form, described
Merck Index, 7th edition, Merck and Co., Inc., Rahway, New Jersey (1960),
page 1584], for 2 hours. The diiodide thereby goes into solution. The ion
exchanger is filtered off and then washed in 3 portions with a total of 1 liter of
water. The combined filtrates are then allowed to run through a column of 300
ml of Amberlite IRA-400 (chloride ion form), rinsed with 300 ml of water and
the eluate evaporated to dryness in a vacuum while excluding air. The residue
gives on recrystallization from methanol/ethanol crystalline pure colorless
diallylnortoxiferine dichloride in a yield of 18.6 g. The compound contains 5
mols of water of crystallization after equilibration in air.
Therapeutic Function
Muscle relaxant
Check Digit Verification of cas no
The CAS Registry Mumber 15180-03-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,1,8 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 15180-03:
(7*1)+(6*5)+(5*1)+(4*8)+(3*0)+(2*0)+(1*3)=77
77 % 10 = 7
So 15180-03-7 is a valid CAS Registry Number.
InChI:InChI=1/C44H50N4O2.2ClH/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49;;/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2;2*1H/q+2;;/p-2/b29-13-,30-14-,33-25-,34-26-;;/t31-,32-,39-,40-,41-,42-,43+,44+,47-,48-;;/m0../s1
