152120-55-3

Basic information

• Product Name: N,N'-BIS-Z-1-GUANYLPYRAZOLE
• Synonyms: Benzyl ((((benzyloxy)carbonyl)aMino)(1H-pyrazol-1-yl)Methylene)carbaMate;Pyrazol(Z)2N,N'-Di-Cbz-1H-pyrazole-1-carbaMidine;N,N'-Di-Cbz-1H-pyrazole-1-carboxamidine;-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine;Pyrazol(Z)2≥ 99% (HPLC);PYRAZOLE(Z)2;N,N'-DI-Z-1H-PYRAZOL-1-CARBAMIDINE;N,N'-BIS-Z-1-GUANYLPYRAZOLE
• CAS NO: 152120-55-3
• Molecular Formula: C₂₀H₁₈N₄O₄
• Molecular Weight: 378.38
• Product Categories: Guanidine Protection/Guanidinylation;Peptide Synthesis;Specialty Synthesis
• Mol File: 152120-55-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 90-96 °C
• Appearance: /
• Density: 1.25 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 6.66±0.46(Predicted)
• CAS DataBase Reference: N,N'-BIS-Z-1-GUANYLPYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-BIS-Z-1-GUANYLPYRAZOLE(152120-55-3)
• EPA Substance Registry System: N,N'-BIS-Z-1-GUANYLPYRAZOLE(152120-55-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 152120-55-3(Hazardous Substances Data)

Usage

Description

N,N'-BIS-Z-1-GUANYLPYRAZOLE, also known as N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine, is a chemical compound with pharmaceutical applications. It is characterized by its off-white powder form and is primarily used as an intermediate in the synthesis of various pharmaceutical products.

Uses

Used in Pharmaceutical Industry:
N,N'-BIS-Z-1-GUANYLPYRAZOLE is used as a pharmaceutical intermediate for the development of various drugs. Its role in the pharmaceutical industry is crucial, as it serves as a building block in the synthesis of new and innovative medications that can potentially treat a wide range of medical conditions.
As a pharmaceutical intermediate, N,N'-BIS-Z-1-GUANYLPYRAZOLE is involved in the production of various drugs, including those that target specific diseases or conditions. Its chemical properties make it a valuable component in the development of new pharmaceuticals, contributing to the advancement of medical treatments and therapies.

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 152120-62-2 (N)-benzyloxycarbonyl-1H-pyrazole-1-carboxamidine 
• 152120-62-2 N-benzyloxycarbonyl-1H-pyrrazole-1-carboxamidine 
• 501-53-1 benzyl chloroformate 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 

Downstream Products

• 181117-79-3 4-[N',N''-bis(benzyloxycarbonyl)guanidino]phenol 
• 221017-18-1 4--1-naphthol 
• 468071-23-0 N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε-methyl-(S)-β-homoarginine tert-butyl ester 
• 253175-09-6 C₂₄H₂₆N₄O₇ 
• 927874-59-7 N,N'-bis(benzyloxycarbonyl)-N-(2-hydroxy-1-hydroxymethyl-ethyl)-guanidine 
• 865304-96-7 C₂₀H₂₃N₃O₅ 
• 476667-20-6 C₁₉H₂₁N₃O₅ 
• 168828-01-1 C₂₀H₂₃N₃O₅ 
• 172965-79-6 N^α-(N,N'-bis-Cbz)amidino-Tyr(Bn)-D-Arg(Cbz2)-Phe-OTce 
• 221017-21-6 6--1-naphthol 
• 221017-20-5 5--2-naphthol 
• 221017-19-2 5--1-naphthol 

Relevant articles and documents

Diaminopyrimidines as P2X3 and P2X2/3 modulators

Compounds of formula (I): wherein R1 and R2 are as defined herein. Also disclosed are methods of making and using the subject compounds.

An efficient method for the preparation of ω,ω'-bis-urethane protected arginine derivatives

Fmoc-Arg(ω,w')(Boc)2-OH and Boc-Arg(ω,w')(Cbz)2-OH were prepared in two steps: Guanylation of Cu(II)-ornithine complex at N(δ) with N,N'-bis urethane protected derivatives of 1-guanylpyrazole, followed by N(α)-protection using either 9-fluorenylmethyl succinimidylcarbonate or di-t-butyl-dicarbonate in the presence of EDTA. The overall yields of these products (2 steps) were 65% and 73%.