152398-91-9

Basic information

• Product Name: N-diphenylmethyl-3,11-dioxo-4-aza-5α-androst-1-ene-17β-carboxamide
• Synonyms: N-diphenylmethyl-3,11-dioxo-4-aza-5α-androst-1-ene-17β-carboxamide
• CAS NO: 152398-91-9
• Molecular Weight: 496.649
• Mol File: 152398-91-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-diphenylmethyl-3,11-dioxo-4-aza-5α-androst-1-ene-17β-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-diphenylmethyl-3,11-dioxo-4-aza-5α-androst-1-ene-17β-carboxamide(152398-91-9)
• EPA Substance Registry System: N-diphenylmethyl-3,11-dioxo-4-aza-5α-androst-1-ene-17β-carboxamide(152398-91-9)

Safety Data

• Hazardous Substances Data: 152398-91-9(Hazardous Substances Data)

Upstream product

• 152398-59-9 11α-acetoxy-3,20-dioxo-4-aza-5α-pregnane 
• 152398-58-8 11α-acetoxy-3,20-dioxo-4-azapregn-5-ene 
• 152398-65-7 (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2,5-dioxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid methyl ester 
• 182926-96-1 11α-acetoxy-20-hydroxy-3-oxo-4-aza-5α-pregnane 
• 152398-57-7 5,20-dioxo-11α-hydroxy-A-nor-3,5-secopregnan-3-oic acid 
• 152398-64-6 (4aR,4bS,5R,6aS,7S,9aS,9bS,11aR)-5-Hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid methyl ester 
• 152398-60-2 (4aR,4bS,5R,6aS,7S,9aS,9bS,11aR)-5-Hydroxy-4a,6a-dimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinoline-7-carboxylic acid methyl ester 
• 125699-03-8 11α-hydroxy-4-aza-5α-pregnan-5-en-3,20-dione 
• 80-75-1 11-alpha-hydroxyprogesterone 
• 152398-55-5 3,11-dioxo-4-aza-5α-androst-1-ene-17β-carboxylic acid 
• 91-00-9 Benzhydrylamine 

Relevant articles and documents

Synthesis and testosterone 5α-reductase inhibitory activity of 11-substituted 4-aza-5α-androstane compounds

11α-Acetoxy-, 11α-hydroxy-, 11β-hydroxy-, and 11-oxo-4-aza-5α-androstane compounds with an N-diphenylmethylcarbamoyl moiety at the C-17 position were synthesized and their inhibitory activities against rat and human testosterone 5α-reductase were tested.Introduction of the 11α-acetoxy, 11α-hydroxy, 11β-hydroxy and 11-oxo groups into 4-aza-5α-androstane compounds reduced the inhibitory activity against rat and human 5α-reductase.The 11α-acetoxy-4-aza-5α-androstane compound in particular lost almost all its activity.However, several compounds with an 11β-hydroxy or 11-oxo group showed inhibitory activities comparable to MK-906.The 4-methyl-11β-hydroxy-4-aza-5α-androstane derivative showed the most potent inhibitory activity against rat and human enzyme, and was more active than MK-906. - Keywords: testosterone 5α-reductase inhibitor; synthesis; 4-aza-5α-androstane; steroid; prostatic hypertrophy