1528636-28-3

Basic information

• Product Name: C₃₄H₅₉ClO₇Si₄
• Synonyms: C₃₄H₅₉ClO₇Si₄
• CAS NO: 1528636-28-3
• Molecular Weight: 727.633
• Mol File: 1528636-28-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₃₄H₅₉ClO₇Si₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₅₉ClO₇Si₄(1528636-28-3)
• EPA Substance Registry System: C₃₄H₅₉ClO₇Si₄(1528636-28-3)

Safety Data

• Hazardous Substances Data: 1528636-28-3(Hazardous Substances Data)

Upstream product

• 714269-57-5 (2S,3R,4S,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)-2-methoxy-tetrahydropyran-3,4,5-triol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 461432-23-5 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene 
• 32469-28-6 (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one 
• 75-77-4 chloro-trimethyl-silane 
• 67-56-1 methanol 

Downstream Products

• 714269-57-5 (2S,3R,4S,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)-2-methoxy-tetrahydropyran-3,4,5-triol 
• 1528636-29-4 ((2R,3R,4S,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methoxy-3,4,5-tris-(trimethylsilyloxy)tetrahydro-2H-pyran-2-yl)methanol 
• 1528636-33-0 (2S,3R,4S,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methoxy-3,4,5-tris-(trimethylsilyloxy)tetrahydro-2H-pyran-2-carbaldehyde 
• 1528636-39-6 (2S,3R,4S,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 1210344-57-2 Ertugliflozin 

Relevant articles and documents

Development of an early-phase bulk enabling route to sodium-dependent glucose cotransporter 2 inhibitor ertugliflozin

The development and optimization of a scalable synthesis of sodium-dependent glucose cotransporter 2 inhibitor, ertugliflozin, for the treatment of type-2 diabetes is described. Highlights of the chemistry are a concise, four-step synthesis of a structurally complex API from known intermediate 4 via persilylation-selective monodesilylation, primary alcohol oxidation, aldol-crossed-Cannizzaro reaction, and solid-phase acid-catalyzed bicyclic ketal formation. The final API was isolated as the Lpyroglutamic acid cocrystal.

Preparation method of synthesis ertugliflozin intermediate

The invention discloses a preparation method of a synthesis ertugliflozin ( Ertugliflozin, compound VII) intermediate as shown in a formula I. The Ertugliflozin is a medicine for treating diabetes mellitus type 2, jointly developed by Merck and Pfizer, and is a bran-new glucose sodium transport protein inhibitor(SGLT-2). The invention provides a preparation route method, and the method has the defects of being long in route, high in analysis difficulty, low in yield and the like. The preparation method comprises the following steps of protecting the compound II with TMS, performing oxidation,and performing disproportionation to generate a compound I. The preparation method for synthesis of the compound I is high in yield, simple and convenient to operate and low in cost, and is suitable for industrial mass production. A new way is provided for preparation of the ertugliflozin.