153207-76-2

Basic information

• Product Name: 1-Propanol, 3-azido-, 4-methylbenzenesulfonate (ester)
• CAS NO: 153207-76-2
• Molecular Formula: C10H13N3O3S
• Molecular Weight: 255.298
• Mol File: 153207-76-2.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1-Propanol, 3-azido-, 4-methylbenzenesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol, 3-azido-, 4-methylbenzenesulfonate (ester)(153207-76-2)
• EPA Substance Registry System: 1-Propanol, 3-azido-, 4-methylbenzenesulfonate (ester)(153207-76-2)

Safety Data

• Hazardous Substances Data: 153207-76-2(Hazardous Substances Data)

Usage

Molecular structure

A propanol molecule attached to a 4-methylbenzenesulfonate ester through an azido group.
The compound consists of a three-carbon alcohol (propanol) connected to a sulfonate ester (4-methylbenzenesulfonate) via an azido group.

Propanol molecule

A three-carbon alcohol with the chemical formula C3H8O.
The propanol part of the compound contains three carbon atoms, eight hydrogen atoms, and one oxygen atom.

4-Methylbenzenesulfonate ester

A derivative of sulfonic acid containing a methyl group attached to a benzene ring.
The ester component of the compound is derived from sulfonic acid and features a methyl group (CH3) connected to a benzene ring.

Azido group

Consists of three nitrogen atoms (N3).
The azido group is a linear arrangement of three nitrogen atoms, which provides the compound with its reactivity.

Reactive properties

The azido group is often used in organic synthesis and chemical reactions, particularly in the preparation of azides.
The presence of the azido group makes the compound highly reactive and useful in various chemical processes, such as the synthesis of azides.

Potential applications

Organic chemistry and as a reagent in chemical reactions and processes.
The compound may be utilized in organic chemistry research and as a reagent in various chemical reactions due to its unique structure and reactivity.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 627-18-9 1-bromo-3-propanol 
• 5469-66-9 propane-1,3-diol ditosylate 
• 71879-76-0 acetic acid 3-azidoprpropyl ester 
• 72320-38-8 3-azidopropan-1-ol 

Downstream Products

• 876400-54-3 1-(3-azido-propoxy)-4-(tris-(4-tert-butyl-phenyl)methyl)benzene 
• 1393889-56-9 C₂₇H₃₄N₆O₆S₂ 
• 1393889-55-8 1,3-diethynylbenzene 
• 1578209-48-9 4-(3-azidopropoxy)-2-methoxybenzaldehyde 
• 1622399-51-2 (S)-N-((3-(4-(4-(3-azidopropyl)piperazin-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide 
• 1535166-44-9 (2-(4-(3-azidopropoxy)phenyl)ethene-1,1,2-triyl)tribenzene 
• 1158651-52-5 C₂₃H₄₃N₃O₃Si₂ 
• 1098100-04-9 C₁₃H₁₈N₆O₃ 

Relevant articles and documents

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system

Polyamines, such as putrescine, spermidine, and spermine, are physiologically important polycations, but the transporters responsible for their uptake in mammalian cells remain poorly characterized. Here, we reveal a new component of the mammalian polyamine transport system using CHO-MG cells, a widely used model to study alternative polyamine uptake routes and characterize polyamine transport inhibitors for therapy. CHO-MG cells present polyamine uptake deficiency and resistance to a toxic polyamine biosynthesis inhibitor methylglyoxal bis-(guanylhydrazone) (MGBG), but the molecular defects responsible for these cellular characteristics remain unknown. By genome sequencing of CHO-MG cells, we identified mutations in an unexplored gene, ATP13A3, and found disturbed mRNA and protein expression. ATP13A3 encodes for an orphan P5B-ATPase (ATP13A3), a P-type transport ATPase that represents a candidate polyamine transporter. Interestingly, ATP13A3 complemented the putrescine transport deficiency and MGBG resistance of CHO-MG cells, whereas its knockdown in WT cells induced a CHO-MG phenotype demonstrated as a decrease in putrescine uptake and MGBG sensitivity. Taken together, our findings identify ATP13A3, which has been previously genetically linked with pulmonary arterial hypertension, as a major component of the mammalian polyamine transport system that confers sensitivity to MGBG.

Biotin-decorated NIR-absorbing nanosheets for targeted photodynamic cancer therapy

Targeted photodynamic therapy (PDT) is one of the promising approaches for the selective killing of cancerous cells without affecting the normal cells, and hence designing new strategies for targeted PDT is extremely important. Herein we report the design and synthesis of a new class of nanosheets derived from the self-assembly of the iodo-BODIPY-biotin conjugate as a photosensitizer for targeted PDT applications. The nanosheet exhibits a high extinction coefficient in the NIR region, high singlet oxygen efficiency, no toxicity in the dark and cell targeting ligands (biotin) on the surface, which are necessary features required for an ideal photosensitizer. Overexpression of sodium-dependent multivitamin transporters (SMVTs) in HeLa and A549 (biotin receptor positive cell lines) is explored for the selective uptake of the nanophotosensitizer through receptor mediated endocytosis (interaction between biotin and SMVT). Control experiments using a biotin receptor negative cell line (WI-38) are also carried out to confirm that the specific interaction between the SMVTs and biotin is mainly responsible for the selective uptake of the photosensitizer. Efficient killing of cancerous cells is demonstrated upon light irradiation through the generation of singlet oxygen and other reactive oxygen species around the cellular environment.

Visualization and quantification of cellular RNA production and degradation using a combined fluorescence and mass spectrometry characterization assay

Here we report a combined fluorescence and mass spectrometry assay which is capable of stably visualizing and quantifying cellular nucleoside-labeled RNA production and degradation. The fluorescence and mass spectrometry signals from cellular labeled RNAs