15373-33-8

Basic information

• Product Name: methyl 2-(3,4-bis(benzyloxy)phenyl)acetate
• Synonyms: methyl 2-(3,4-bis(benzyloxy)phenyl)acetate
• CAS NO: 15373-33-8
• Molecular Weight: 362.425
• Mol File: 15373-33-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 2-(3,4-bis(benzyloxy)phenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(3,4-bis(benzyloxy)phenyl)acetate(15373-33-8)
• EPA Substance Registry System: methyl 2-(3,4-bis(benzyloxy)phenyl)acetate(15373-33-8)

Safety Data

• Hazardous Substances Data: 15373-33-8(Hazardous Substances Data)

Upstream product

• 25379-88-8 2-(3,4-dihydroxyphenyl)acetic acid methyl ester 
• 100-44-7 benzyl chloride 
• 102-32-9 3,4-dihydroxyphenylacetate 

Downstream Products

• 96826-11-8 2-<3,4-bis(benzyloxy)phenyl>ethanol 

Relevant articles and documents

Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase

A new class of inhibitors of HIV-1 reverse transcriptase obtained by the systematic structural simplification of epicatechin and epigallocatechin gallates are also shown here to inhibit DNA-strand-transfer, a process critical to the completion of the HIV-1-RT reproduction and to recombination-associated mutation of the virus. Up to 80-fold selectivity for DNA-strand-transfer inhibition over polymerase inhibition was observed for a defined subset of these agents. Such specific DNA-strand-transfer inhibitors may have important therapeutic potential.

Synthesis and antioxidant activity of conjugates of hydroxytyrosol and coumarin

Antioxidants have been the subject of intense research interest due to their numerous health benefits. In this work, a series of new conjugates of hydroxytyrosol and coumarin were synthesized and evaluated for their free radical scavenging, toxicity and antioxidant mechanism in vitro. The all target compounds 14a–t exhibited better radical scavenging activity than BHT, hydroxytyrosol, and coumarin in both DPPH radical and ABTS+ radical cation scavenging assays. The structure-activity relationships study indicated that the number and position of hydroxyl groups on the coumarin ring were vital to a good antioxidant capacity. Furthermore, the most promising compound 14q showed less toxicity in hemolysis assay and weaker antiproliferative effects than BHT against normal WI-38 and GES cells, and enhanced viability of H2O2-induced HepG2 cells. Additionally, 14q decreased the apoptotic percentage of HepG2 cells, reduced the ROS produce and LDH release, and improved GSH and SOD levels in H2O2-treated HepG2 cells. Lastly, 14q exhibited more stability than hydroxytyrosol in methanol solution. These results revealed that conjugations of hydroxytyrosol and coumarin show better antioxidant capacity, and are the efficacious approach to finding novel potential antioxidant.