154-69-8

Basic information

• Product Name: TRIPELENNAMINE HYDROCHLORIDE
• Synonyms: 2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinmonohydrochloride;2-ethanediamine,n,n-dimethyl-n’-(phenylmethyl)-n’-2-pyridinyl-monohydroc;dehistin;dehistinmonohydrochloride;n(sup1)-alpha-pyridyl-n(sup1)-benzyl-n,n-dimethylethylenediaminemonohydro;n,n-dimethyl-n’-(2-pyridyl)-n’-benzylethylenediaminehydrochloride;n-benzyl-n’,n’-dimethyl-n-(2-pyridyl)-ethylenediaminhydrochloride;n-benzyl-n’,n’-dimethyl-n-2-pyridyl-ethylenediaminehydrochloride
• CAS NO: 154-69-8
• Molecular Formula: C16H22ClN3
• Molecular Weight: 291.82
• EINECS: 205-833-5
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical raw material;API
• Mol File: 154-69-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 192-193℃
• Boiling Point: 387.8 °C at 760 mmHg
• Flash Point: 188.3 °C
• Appearance: White solid
• Density: 1.20
• Vapor Pressure: 3.21E-06mmHg at 25°C
• Storage Temp.: Refrigerator
• CAS DataBase Reference: TRIPELENNAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIPELENNAMINE HYDROCHLORIDE(154-69-8)
• EPA Substance Registry System: TRIPELENNAMINE HYDROCHLORIDE(154-69-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: US3150000
• Hazardous Substances Data: 154-69-8(Hazardous Substances Data)

Usage

Description

Tripelennamine hydrochloride, also known as PBZ, is a first-generation antihistamine that is well absorbed when given orally. It is a white crystalline powder or solid with a bitter taste, which darkens slowly on exposure to light. The compound is soluble in water and alcohol, has a pKa of about 9, and exhibits neutral to litmus solutions. Tripelennamine hydrochloride is effective in treating various conditions and may have fewer side reactions compared to other antihistamines, although drowsiness may occur.

Uses

Used in Pharmaceutical Industry:
Tripelennamine hydrochloride is used as an antihistamine for the treatment of various allergic conditions such as asthma, hay fever, and urticaria. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Used in Drug Delivery Systems:
While the provided materials do not specifically mention drug delivery systems for Tripelennamine hydrochloride, it can be inferred that the compound may be utilized in developing novel drug delivery systems to enhance its efficacy and bioavailability in treating allergic conditions. This could involve the use of various carriers and formulations to improve the compound's delivery and therapeutic outcomes.

Air & Water Reactions

Water soluble.

Reactivity Profile

TRIPELENNAMINE HYDROCHLORIDE behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Fire Hazard

Flash point data for TRIPELENNAMINE HYDROCHLORIDE are not available; however, TRIPELENNAMINE HYDROCHLORIDE is probably combustible.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Tripelennamine has been used as a CNS stimulant in “Downer cows” when administered slow IV.

InChI:InChI=1/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H

Synthetic route

hydrogenchloride (7647-01-0) + cobalt(II) chloride hexahydrate + tripelennamine hydrochloride (154-69-8) → N-benzyl-N',N'-dimethyl-N-(2-pyridinio)-1,2-ethanediammonium tetrachlorocobaltate(II) (220156-62-7)

Conditions	Yield
In hydrogenchloride equimolar amts. of CoCl2 and ligand, 6 M HCl; crystn. overnight, washing (EtOH), recrystn. (MeCN, room temp., slow evapn);

tripelennamine hydrochloride (154-69-8) + cucurbit[7]uril → tripelennamine monohydrochloride-cucurbit[7]uril 1:1 complex

Conditions	Yield
In water pH=8;

Downstream Products

• 220156-62-7 N-benzyl-N',N'-dimethyl-N-(2-pyridinio)-1,2-ethanediammonium tetrachlorocobaltate(II) 

Related news

Electro‐oxidation and Determination of TRIPELENNAMINE HYDROCHLORIDE (cas 154-69-8) at MWCNT‐CTAB Modified Glassy Carbon Electrode09/28/2019

An electrochemical method for the determination of tripelennamine hydrochloride (TPA) using cetyltrimethylammoniumbromide‐multiwalled carbon nanotubes modified glassy carbon electrode (MWCNT‐CTAB/GCE) was developed. Because of good electrical conductivity of MWCNT and catalytic behavior of CTA...detailed