154366-93-5Relevant articles and documents
Synthesis and reactions of some new thienopyrimidines
Moneam, Maisa I. Abdel,Geies, Ahmed A.,El-Naggar, Galal M.,Mussa, Suliman M.
, p. 737 - 751 (2007/10/03)
4-Methyl-6-mercapto-2-phenylpyrimidine-5-carbonitrile (1) was reacted with different halo compounds, namely ethylchloroacetate, chloroacetone, bromoacetanilide, p-chlorobromoacetanilide, and p-methoxy chloroacetanilide in ethanol in the presence of sodium acetate yielded the corresponding S-alkylated derivatives (2a-e). The latter compounds underwent cyclization into thienopyrimidines (4a-e) upon treatment with sodium ethoxide in ethanol. The reaction of (4a) with hydrazine hydrate led to the formation of 5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine-2-carbohydrazide (5). Compound (5) was reacted with a variety of reagents to produce other new thienopyrimidines as well as oxadiazolylthienopyrimidines (6, 11).
Synthesis of some pyrimidothienopyrimidine derivatives
Kamal El-Dean, Adel M.
, p. 523 - 533 (2007/10/03)
The pyrimidothienopyrimidines 5 and 6 have been synthesized via the reaction of compounds 4a, b with CS2 and were further transformed to related fused heterocyclic systems.