154660-55-6

Basic information

• Product Name: (+/-)-2-(2-phenylbenzylidene)-3-(2-methoxybenzylamino)quinuclidine
• Synonyms: (+/-)-2-(2-phenylbenzylidene)-3-(2-methoxybenzylamino)quinuclidine
• CAS NO: 154660-55-6
• Molecular Weight: 410.559
• Mol File: 154660-55-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+/-)-2-(2-phenylbenzylidene)-3-(2-methoxybenzylamino)quinuclidine(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-2-(2-phenylbenzylidene)-3-(2-methoxybenzylamino)quinuclidine(154660-55-6)
• EPA Substance Registry System: (+/-)-2-(2-phenylbenzylidene)-3-(2-methoxybenzylamino)quinuclidine(154660-55-6)

Safety Data

• Hazardous Substances Data: 154660-55-6(Hazardous Substances Data)

Upstream product

• 947-84-2 2-Biphenylcarboxylic acid 
• 154660-50-1 (Z)-2-(2-phenylbenzylidene)-3-quinuclidinone 
• 154660-49-8 N-(2-phenylbenzoyl)-N'-benzensulfonylhydrazine 
• 154660-48-7 [1,1′-biphenyl]-2-carbohydrazide 
• 1203-68-5 2-Phenylbenzaldehyde 
• 3731-38-2 3-Quinuclidinone 
• 16605-99-5 biphenyl-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and neurokinin antagonist activity of 2-benzylidene- and 2- benzyl-3-benzylamino quinuclidines

Molecular modeling studies based on the potent NK-1 antagonist CP-96,345 led us to the identification of some 2-benzylidene- and 2-benzyl-3- benzylaminoquinuclidine derivatives as potential antagonists at the NK receptor subtypes. The synthesized compounds, whose Z/E isomerism has been defined by X-ray analysis, show only moderate potency on the three neurokinin receptors. The possible reasons of the low potency exhibited by the tested compounds are discussed.