154919-93-4Relevant articles and documents
Simplified discodermolide analogues: Synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents
Choy, Nakyen,Shin, Youseung,Nguyen, Phu Qui,Curran, Dennis P.,Balachandran, Raghavan,Madiraju, Charitha,Day, Billy W.
, p. 2846 - 2864 (2007/10/03)
Several novel analogues of (+)-discodermolide were synthesized via a convergent strategy that used Wittig reactions to append left and right side chains to a central scaffold and then tested for biological activity. Three of the analogues in the 4-epi-7-d
The asymmetric syntheses of the C-1 sidechains of zaragozic acid A and zaragozic acid C
Robichaud, Albert J.,Berger, Gregory D.,Evans, David A.
, p. 8403 - 8406 (2007/10/02)
The asymmetric syntheses of the C-1 sidechains of zaragozic acid A and C are described. Aldol reaction defines the chirality at C-4' and C-5' in two independent routes. Multigram preparation as well as a route amenable to derivatization are highlights of