156629-52-6

Basic information

• Product Name: Benzoic acid, 4-(1-methylethoxy)-3-nitro-
• CAS NO: 156629-52-6
• Molecular Formula: C10H11NO5
• Molecular Weight: 225.201
• Mol File: 156629-52-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(1-methylethoxy)-3-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(1-methylethoxy)-3-nitro-(156629-52-6)
• EPA Substance Registry System: Benzoic acid, 4-(1-methylethoxy)-3-nitro-(156629-52-6)

Safety Data

• Hazardous Substances Data: 156629-52-6(Hazardous Substances Data)

Upstream product

• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 67-63-0 isopropyl alcohol 
• 13205-46-4 4-isopropoxybenzoic acid 

Downstream Products

• 1038969-94-6 (4-isopropoxy-3-nitrophenyl)methanol 
• 125872-99-3 4-isopropoxy-3-nitrobenzaldehyde 
• 1345411-98-4 3-(4-Imidazol-1-ylmethyl-phenyl)-5-(4-isopropoxy-3-nitro-phenyl)-[1,2,4]oxadiazole 

Relevant articles and documents

N-(3-nitro-4-alkoxybenzoyl)amino acid compounds as well as preparation method and application thereof

The invention discloses N-(3-nitro-4-alkoxybenzoyl)amino acid compounds as well as a preparation method and an application thereof and belongs to the field of medicines. 4-hydroxy-3-nitrobenzoic acidis subjected to methanol esterification, bromo-alkane substitution, hydrolysis and chlorination and then acylated with L-phenylglycine, R2 which is L-phenylglycine sodium salt is obtained, and the N-(3-nitro-4-alkoxybenzoyl)amino acid compounds are obtained after hydrolysis. The N-(3-nitro-4-alkoxybenzoyl)amino acid compounds have novel chemical structures, have good effects in an in-vitro xanthine oxidase inhibition activity test and can be used for treating and preventing gout diseases.

PROCESS FOR PRODUCING 3-NITRO-4-ALKOXYBENZOIC ACID

The present invention provides a process for preparing 3-nitro-4-alkoxybenzoic acid, which comprises the step of subjecting a mixture comprising 4-alkoxybenzoic acid and 40-80% nitric acid, wherein the amount of the 40-80% nitric acid is equal to or more than 8 times that of 4-alkoxybenzoic acid by weight, to a reaction at a temperature of 30-100°C.