1567847-28-2Relevant articles and documents
Base-catalyzed stereoselective intermolecular addition of imidazoles onto alkynes: An easy access to imidazolyl enamines
Patel, Monika,Saunthawal, Rakesh K.,Verma, Akhilesh K.
supporting information, p. 1310 - 1315 (2014/03/21)
An efficient transition metal-free approach for the regio- and stereoselective addition of imidazoles 1a-f onto alkynes 2a-l to provide the Z- and E isomers of imidazolyl enamines 3a-q and 4a-d using catalytic amount of KOH is described. Stereoselectivity of the addition products (Z and E isomer) was found to be dependent upon time. Competitive experiments show that imidazole is less reactive than pyrrole and more reactive than aniline towards hydroamination.
