1583-65-9Relevant articles and documents
Conformational flexibility of tetralactam macrocycles and their intermolecular hydrogen-bonding patterns in the solid state
Zhu, Sascha S.,Nieger, Martin,Daniels, Joerg,Felder, Thorsten,Kossev, Iordan,Schmidt, Thomas,Sokolowski, Moritz,Voegtle, Fritz,Schalley, Christoph A.
experimental part, p. 5040 - 5046 (2009/12/26)
Despite their rigid scaffold, tetralactam macrocycles (TLMs) display a remarkable degree of conformational flexibility, as revealed by analysis of the corresponding X-ray crystal structures. This flexibility is not limited to the rotatability of the TLM amide groups but also applies to the m-xylene rings, and it thus has a great impact on the overall shape of the macrocycle cavity. The conformational properties of the TLMs give rise to a broad variety of intermolecular hydrogen-bonding patterns, including infinite ladders, an interesting catemer motif, and short C-H... O=C hydrogen bonds. These results are in accord with previous theoretical calculations, support a structural model proposed earlier for an interpretation of scanning tunneling microscopy images, and substantially contribute to the understanding of the adaptability of macrocyclic scaffolds, which is crucial for guest binding or templated syntheses with TLMs.
Macrolactams by engineered biosynthesis
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Page/Page column 15, (2008/12/07)
Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynt
A lockable light-driven molecular shuttle with a fluorescent signal
Wang, Qiao-Chun,Qu, Da-Hui,Ren, Jun,Chen, Kongchang,Tian, He
, p. 2661 - 2665 (2007/10/03)
A turn on! A lockable photodriven molecular shuttle is based on a [2]rotaxane that consists of an α-cyclodextrin threaded by a stilbene derivative. The fluorescent signals originate from the naphthalimide stopper and indicate the position of the shuttle. Once unlocked, the device can be turned on by irradiation at 335 nm and turned off by irradiation at 280 nm. The shuttle can be locked or unlocked by the addition acid or alkali, respectively (see picture).
