1584713-87-0

Basic information

• Product Name: BMS-983970
• Synonyms: BMS-983970
• CAS NO: 1584713-87-0
• Molecular Formula: C₂₆H₂₆F₄N₄O₃
• Molecular Weight: 518.5
• Mol File: 1584713-87-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 730.2±60.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• PKA: 10.57±0.70(Predicted)
• CAS DataBase Reference: BMS-983970(CAS DataBase Reference)
• NIST Chemistry Reference: BMS-983970(1584713-87-0)
• EPA Substance Registry System: BMS-983970(1584713-87-0)

Safety Data

• Hazardous Substances Data: 1584713-87-0(Hazardous Substances Data)

Usage

Description

BMS-983970, also known as Galunisertib, is a small molecule inhibitor of the TGF-β receptor kinase. It has shown promising results in preclinical studies for the treatment of various types of cancer, such as pancreatic, colorectal, and glioblastoma. Its ability to block the activity of the TGF-β pathway, which is known to promote tumor growth, invasion, and metastasis, makes it a potential therapeutic agent for cancer treatment.

Uses

Used in Oncology:
BMS-983970 is used as an anticancer agent for its potential therapeutic efficacy in treating various types of cancer, such as pancreatic, colorectal, and glioblastoma. It works by inhibiting the TGF-β pathway, which plays a crucial role in tumor growth, invasion, and metastasis.
Used in Clinical Trials:
BMS-983970 is used as a candidate for clinical trials to evaluate its safety and effectiveness as a single agent or in combination with other cancer treatments. It is currently being investigated for its potential in the treatment of solid tumors and fibrosis.
Used in Pharmaceutical Research:
BMS-983970 is used as a subject of research to further understand its mechanism of action, safety, and potential applications in the treatment of cancer and other diseases. Further research is needed to determine its full therapeutic potential and to develop strategies for its optimal use in clinical settings.

Upstream product

• 1581734-68-0 (2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate 
• 1581734-69-1 (2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate 
• 93958-21-5 t-butyl-3-(cyclopropyl)-propanoate 
• 1401067-00-2 (4S)-4-(propan-2-yl)-3-(5,5,5-trifluoropentanoyl)-1,3-oxazolidin-2-one 
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• 1584714-99-7 3-amino-9-fluoro-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one 
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Downstream Products

• 1584714-67-9 ((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl L-valinate 
• 1584715-84-3 ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate 
• 1584714-69-1 ((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl 1-aminocyclopropanecarboxylate 
• 1584714-12-4 (2R,3S)-3-(cyclopropylmethyl)-N-((3S)-9-fluoro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide 
• 1584715-75-2 (R)-tert-butyl 2-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-2-(cyclopropylmethyl)-6,6,6-trifluoro-3-(((S)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)hexanamido)thio)propanoate 
• 1584715-77-4 tert-butyl 2-((2S,3R)-2-(cyclopropylmethyl)-6,6,6-trifluoro-3-((S,Z)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)hexanamidothio)ethylcarbamate 
• 1584715-79-6 (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-2-(cyclopropylmethyl)-6,6,6-trifluoro-3-(((S)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)hexanamido)thio)propanoate 
• 1584714-70-4 (2S,3R)-2-(cyclopropylmethyl)-N₄-((3S)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-N₁-(1-pyrrolidinylmethyl)-3-(3,3,3-trifluoropropyl)succinamide 

Relevant articles and documents

ALKYL, FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS

Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein: R1 is CH2CH2CF3; R2 is CH2(cyclopropyl), CH(CH3)(cyclopropyl), or CH2CH2CH3/