15873-51-5

Basic information

• Product Name: 4-NITROANILINE HYDROCHLORIDE
• Synonyms: P-NITRANILINE HYDROCHLORIDE;P-NITROANILINE HYDROCHLORIDE;1-AMINO-4-NITROBENZENE HYDROCHLORIDE;4-NITROPHENYLAMINE HYDROCHLORIDE;4-NITROANILINE HYDROCHLORIDE;4-nitro-benzenaminmonohydrochloride;4-nitroanilinium chloride;1-Amino-4-nitrobenzeneHCl
• CAS NO: 15873-51-5
• Molecular Formula: C₆H₆N₂O₂*ClH
• Molecular Weight: 174.58
• EINECS: 239-997-4
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 15873-51-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 145-146 °C
• Boiling Point: 211.6°Cat760mmHg
• Flash Point: 84.2°C
• Appearance: /
• Density: 0.94g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-NITROANILINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITROANILINE HYDROCHLORIDE(15873-51-5)
• EPA Substance Registry System: 4-NITROANILINE HYDROCHLORIDE(15873-51-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 15873-51-5(Hazardous Substances Data)

Usage

General Description

4-Nitroaniline hydrochloride is a chemical compound that is often used in research and laboratory settings. It is a derivative of aniline, with a nitro group attached to the benzene ring. The hydrochloride salt form of this compound is commonly used in organic chemistry reactions as a source of the 4-nitroaniline molecule. It is also used in the production of dyes, pharmaceuticals, and agrochemicals. However, it is important to handle this compound with care as it is toxic and can cause irritation to the skin, eyes, and respiratory system. Additionally, it should be stored in a cool, dry place and kept away from sources of ignition.

InChI:InChI=1/C6H6N2O2.ClH/c7-5-1-3-6(4-2-5)8(9)10;/h1-4H,7H2;1H

Upstream product

• 74234-60-9 (2-Methoxy-6-{[(E)-4-nitro-phenylimino]-methyl}-8,9-dihydro-7H-benzocyclohepten-5-yl)-(4-nitro-phenyl)-amine; hydrochloride 
• 100-01-6 4-nitro-aniline 
• 100-25-4 para-dinitrobenzene 
• 1516-60-5 4-nitrophenyl azide 
• 16135-31-2 p-nitroformanilide 
• 17329-87-2 2-chloro-N-(4-nitro-phenyl)-acetamide 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 734-25-8 N-(4-nitrophenyl)-4-methylbenzenesulfonamide 
• 142-04-1 aniline hydrochloride 

Downstream Products

• 7404-20-8 6-methoxy-3,4-dihydro-2H-quinoline-1-carbonimidic acid-(4-nitro-anilide) 
• 35372-32-8 N-(4-nitro-phenyl)-acetamidine 
• 35773-20-7 N,N'-bis-(4-nitro-phenyl)-acetamidine 
• 40824-92-8 2-nitro-3-(4-nitro-anilino)-acrylaldehyde 
• 7147-77-5 5-(4-nitrophenyl)-2-furaldehyde 
• 79344-67-5 6-(4-nitrophenylamino)-1H-pyrimidine-2,4-dione 
• 3393-96-2 p-nitrobenzanilide 
• 59243-28-6 1,2-Dichlor-cyclopenten-(1)-trion-(3,4,5)-<4-nitro-phenylhydrazon)-(4)> 
• 92858-92-9 Azulene-1-azo(4'-nitrobenzene) 
• 113934-26-2 1-(4-nitrophenyl)-1H-1,2,3-triazole-4-carboxaldehyde 
• 586-78-7 para-nitrophenyl bromide 
• 920849-76-9 1-methyl-3-(4-nitrophenylamino)pyrrole-2,5-dione 

Relevant articles and documents

Synthesis and evaluation of some benzothiazole derivatives as antidiabetic agents

Objective: The objective of the present research investigation involves synthesis and biological evaluation of antidiabetic activity of benzothiazole derivatives. Methods: A novel series of benzothiazole derivatives 7(a-l) were synthesised and synthesised compounds were characterised for different physical and chemical properties like molecular formula, molecular weight, melting point, percentage yield, Rf value, IR,1HNMR,13CNMR and mass spectroscopy. The newly synthesised benzothiazole derivatives were subsequently assayed in vivo to investigate their hypoglycemic activity by the alloxan-induced diabetic model in rats. Results: All the synthesised derivatives showed significant biological efficacy. The compound 7d at 350 mg/kg exerted maximum glucose lowering effects whereas 7c showed minimum glucose lowering effects. All the compounds were effective, and experimental results were statistically significant at p0.01 and p0.05 level. Conclusion: From the results, it is clear that compound 7d demonstrated potent anti-diabetic activity and would be of better use in drug development to combat the metabolic disorder in future.

Cyclometalated Ruthenium(II) NHC Complexes with Imidazo[1,5-a]pyridine-Based (C^C*) Ligands – Synthesis and Characterization

We present the synthesis and characterization of cyclometalated ruthenium(II) NHC complexes with phenyl-substituted imidazo[1,5-a]pyridine C^C* ligands. The corresponding p-cymene complexes can be reacted with bipyridine to form bisheteroleptic ruthenium(II) dyes. The compounds have been characterized by one- and two-dimensional 1H/13C NMR spectroscopy, elemental analysis, cyclic voltammetry, infrared spectroscopy, as well as solid-state structure (X-ray) analysis.

The ortho effect on the acidic and alkaline hydrolysis of substituted formanilides

The kinetics of formanilides hydrolysis were determined under first-order conditions in hydrochloric acid (0.01-8 M, 20-60°C) and in hydroxide solutions (0.01-3 M, 25 and 40°C). Under acidic conditions, second-order specific acid catalytic constants were used to construct Hammett plots. The ortho effect was analyzed using the Fujita-Nishioka method. In alkaline solutions, hydrolysis displayed both first- and second-order dependence in the hydroxide concentration. The specific base catalytic constants were used to construct Hammett plots. Ortho effects were evaluated for the first-order dependence on the hydroxide concentration. Formanilide hydrolyzes in acidic solutions by specific acid catalysis, and the kinetic study results were consistent with the AAC2 mechanism. Ortho substitution led to a decrease in the rates of reaction due to steric inhibition of resonance, retardation due to steric bulk, and through space interactions. The primary hydrolytic pathway in alkaline solutions was consistent with a modified BAC2 mechanism. The Hammett plots for hydrolysis of meta- and para-substituted formanilides in 0.10 M sodium hydroxide solutions did not show substituent effects; however, ortho substitution led to a decrease in rate constants proportional to the steric bulk of the substituent.