1595145-00-8

Basic information

• Product Name: (S)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)azetidine-2-carboxamide
• Synonyms: (S)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)azetidine-2-carboxamide
• CAS NO: 1595145-00-8
• Molecular Weight: 409.798
• Mol File: 1595145-00-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)azetidine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)azetidine-2-carboxamide(1595145-00-8)
• EPA Substance Registry System: (S)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)azetidine-2-carboxamide(1595145-00-8)

Safety Data

• Hazardous Substances Data: 1595145-00-8(Hazardous Substances Data)

Upstream product

• 705-24-8 4,6-dichloro-2-(trifluoromethyl)pyrimidine 
• 167762-80-3 4‐(2‐aminoethyl)benzonitrile hydrochloride 

Downstream Products

• 1595145-01-9 (2S)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]azetidine-2-carboxamide 
• 1595145-22-4 4-[(1-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]benzoic acid 
• 1595145-20-2 (S)-2-(4-((1-(6-(2-((4-cyanophenylethyl)carbamoyl)azetidin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)piperidin-4-yl)oxy)phenyl)acetic acid 
• 1595145-31-5 4-(1-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)-2-methoxybenzoic acid 
• 1595145-35-9 (S)-methyl 4'-(6-(2-((4-cyanophenylethyl)carbamoyl)azetidin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)-[1,1'-biphenyl]-4-carboxylate 
• 1595145-37-1 4-(4-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}phenyl)benzoic acid 
• 1595145-42-8 trans-methyl 4-(4-(6-((S)-2-((4-cyanophenylethyl)carbamoyl)azetidin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)phenyl)cyclohexanecarboxylate 
• 1595145-44-0 4-(4-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}phenyl)cyclohexane-1-carboxylic acid 

Relevant articles and documents

NOVEL NON-SYSTEMIC TGR5 AGONISTS

The present invention relates to tricyclic compounds of formula (I) and formula (II), or a pharmaceutically acceptable salt thereof. The present tricyclic compounds are useful non-sytemic TGR5 agonists that can be used to treat diabetic diseases in human. The present invention provides a pharmaceutical composition containing tricyclic compounds of formula (I) and formula (II) and a method of making as well as a method of using same in treating patients inflicted with metabolic disorders by administering same. The compounds of the present invention may be used in combination with additional anti-diabetic drugs.