159820-24-3

Basic information

• Product Name: {[3,5-Bis(trifluoromethyl)phenyl]methyl}(methyl)amine
• Synonyms: {[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amine;159820-24-3;1-[3,5-bis(trifluoromethyl)phenyl]-N-methylmethanamine;1-(3,5-Bis(trifluoromethyl)phenyl)-N-methylmethanamine;SCHEMBL681508;(3,5-bis(trifluoromethyl)phenyl)-N-methylmethanamine;AKOS020235258;CS-0180970;(3,5-bis-trifluoromethyl-benzyl)-methylamine;(3,5-bis-trifluoromethyl-benzyl)-methyl-amine;EN300-206498;N-(3,5-bistrifluoromethylbenzyl)-N-methylamine;{[3,5-bis(trifluoromethyl)phenyl]methyl}methylamine
• CAS NO: 159820-24-3
• Molecular Formula: C10H9F6N
• Molecular Weight: 257.179
• Mol File: 159820-24-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: {[3,5-Bis(trifluoromethyl)phenyl]methyl}(methyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: {[3,5-Bis(trifluoromethyl)phenyl]methyl}(methyl)amine(159820-24-3)
• EPA Substance Registry System: {[3,5-Bis(trifluoromethyl)phenyl]methyl}(methyl)amine(159820-24-3)

Safety Data

• Hazardous Substances Data: 159820-24-3(Hazardous Substances Data)

Usage

Description

[3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine is a chemical compound that features a phenyl group with two trifluoromethyl substituents at the 3 and 5 positions, a methyl group attached to the central carbon atom of the phenyl group, and an amine group connected to the methyl group. [3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine is known for its strong electron-withdrawing properties due to the trifluoromethyl groups and its amine functionality, making it a valuable reagent for a variety of chemical transformations. The presence of the phenyl group also allows for aromatic chemistry and substitution reactions, contributing to its versatility and importance in organic chemistry.

Uses

Used in Pharmaceutical Industry:
[3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine is used as an intermediate in the synthesis of various pharmaceutical compounds due to its unique structural features and reactivity. The strong electron-withdrawing nature and amine functionality enable the creation of a wide range of drug candidates with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, [3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine serves as a key building block for the creation of complex organic molecules. Its electron-withdrawing properties and amine group facilitate various chemical transformations, making it a useful reagent for the development of new compounds with specific properties and applications.
Used in Material Science:
[3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine is also utilized in material science for the development of novel materials with unique properties. [3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine's structural characteristics and reactivity can be harnessed to create materials with enhanced performance in areas such as electronics, coatings, and adhesives.
Used in Research and Development:
[3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine is frequently employed in research and development settings to explore new reaction pathways, study the effects of electron-withdrawing groups on molecular properties, and develop new synthetic methods. Its versatility and reactivity make it an essential tool for advancing the field of organic chemistry and related disciplines.

Upstream product

• 401-95-6 3,5-Bis(trifluoromethyl)benzaldehyde 
• 74-89-5 methylamine 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 74-88-4 methyl iodide 
• 75462-59-8 3,5-bis(trifluoromethyl)benzyl chloride 

Downstream Products

• 334477-11-1 2-(4-Fluoro-2-methyl-phenyl)-3-oxo-piperazine-1-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide 
• 311335-46-3 5-(2-Chloro-phenyl)-2-dimethylaminomethyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide 
• 311335-44-1 5-(2-Chloro-phenyl)-2-morpholin-4-ylmethyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide 
• 311335-45-2 5-(2-chloro-phenyl)-2-[(2-dimethylamino-ethylamino)-methyl]-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide 
• 311335-43-0 5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-ylmethyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide 
• 311335-81-6 2-chloromethyl-5-(2-chloro-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide 
• 311335-82-7 methanesulfonic acid 4-[(3,5-bis-trifluoromethyl-benzyl)-methyl-carbamoyl]-5-(2-chloro-phenyl)-pyrimidin-2-ylmethyl ester 

Relevant articles and documents

Bifunctional Br?nsted Base Catalyst Enables Regio-, Diastereo-, and Enantioselective Cα-Alkylation of β-Tetralones and Related Aromatic-Ring-Fused Cycloalkanones

The catalytic asymmetric synthesis of both α-substituted and α,α-disubstituted (quaternary) β-tetralones through direct α-functionalization of the corresponding β-tetralone precursor remains elusive. A designed Br?nsted base-squaramide bifunctional catalyst promotes the conjugate addition of either unsubstituted or α-monosubstituted β-tetralones to nitroalkenes. Under these reaction conditions, not only enolization, and thus functionalization, occurs at the α-carbon atom of the β-tetralone exclusively, but adducts including all-carbon quaternary centers are also formed in highly diastereo- and enantioselective manner.

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS

The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(=O)OR7 or C1-4 alkyl optionally substituted with hyd

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.