159877-11-9

Basic information

• Product Name: (S)-2-Benzyloxycarbonylamino-5-(5-methyl-2-nitro-phenylsulfanyl)-pentanoic acid tert-butyl ester
• CAS NO: 159877-11-9
• Molecular Weight: 474.578
• Mol File: 159877-11-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-Benzyloxycarbonylamino-5-(5-methyl-2-nitro-phenylsulfanyl)-pentanoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Benzyloxycarbonylamino-5-(5-methyl-2-nitro-phenylsulfanyl)-pentanoic acid tert-butyl ester(159877-11-9)
• EPA Substance Registry System: (S)-2-Benzyloxycarbonylamino-5-(5-methyl-2-nitro-phenylsulfanyl)-pentanoic acid tert-butyl ester(159877-11-9)

Safety Data

• Hazardous Substances Data: 159877-11-9(Hazardous Substances Data)

Upstream product

• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 159877-09-5 tert-butyl (2S)-5-methylsulphonyloxy-2-(benzyloxycarbonylamino)pentanoate 
• 124620-51-5 (S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-5-hydroxypentanoate 

Relevant articles and documents

Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase

Nitric oxide (NO·) is an important biomodulator of many physiological processes. The inhibition of inappropriate production of NO' by the isoforms of nitric oxide synthase (NOS) has been proposed as a therapeutic approach for the treatment of stroke, inflammation, and other processes. In this study, certain 2-nitroaryl-substituted amino acid analogues were discovered to inhibit NOS. Analogues bearing a 5-methyl substituent on the aromatic ring demonstrated maximal inhibitory potency. For two selected inhibitors, investigation of the kinetics of the enzyme showed the inhibition to be competitive with L-arginine. Additionally, functional NOS inhibition in tissue preparations was demonstrated.