1601497-22-6

Basic information

• Product Name: 4-methyl-2-phenyl-5,5,5-trifluoro-2(E)-pentenal
• Synonyms: 4-methyl-2-phenyl-5,5,5-trifluoro-2(E)-pentenal
• CAS NO: 1601497-22-6
• Molecular Weight: 228.214
• Mol File: 1601497-22-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methyl-2-phenyl-5,5,5-trifluoro-2(E)-pentenal(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2-phenyl-5,5,5-trifluoro-2(E)-pentenal(1601497-22-6)
• EPA Substance Registry System: 4-methyl-2-phenyl-5,5,5-trifluoro-2(E)-pentenal(1601497-22-6)

Safety Data

• Hazardous Substances Data: 1601497-22-6(Hazardous Substances Data)

Upstream product

• 100-59-4 phenylmagnesium chloride 
• 1601497-21-5 4-methyl-2-phenyl-5,5,5-trifluoro-2,3-pentadienol 
• 1601497-44-2 C₁₂H₁₇F₃O₅S 

Relevant articles and documents

Sodium iodide/tert-butyl(dimethyl)silyl chloride-induced isomerization of 2,3-allenols to 2(E)-enals

Through an unexpected C=C bond migration, 2(E)-enals were efficiently prepared highly stereoselectively in moderate to good yields via the sodium iodide/tert-butyl(dimethyl)silyl chloride (NaI/TBSCl)-mediated reaction of the easily available 2,3-allenols. Based on a careful mechanistic study, including control experiments and deuterium-labeling experiments, an electron-withdrawing substituent group in the 4 position has been proven to be crucial and a possible mechanism has been proposed.