161095-99-4Relevant articles and documents
A straightforward synthesis of functionalized cis-perhydroisoquinolin-1-ones
Arioli, Federica,Pérez, Maria,Are, Celeste,Molins, Elies,Bosch, Joan,Amat, Mercedes
, (2019)
Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones.