161582-11-2 Usage
Description
(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE, also known as Ro 48-8071, is an aromatic ketone derivative that functions as an inhibitor of oxidosqualene cyclase (OSC). (4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE is characterized by the replacement of the hydrogen at position 4 (meta to the fluoro group) with a 6-[methyl(prop-2-en-1-yl)amino]hexyloxy group in 2-fluoro-4'-bromobenzophenone. It plays a significant role in the cholesterol synthetic pathway by inhibiting the cyclization of monooxidosqualene to lanosterol.
Uses
Used in Pharmaceutical Industry:
Ro 48-8071 is used as a cholesterol-lowering agent for its ability to inhibit oxidosqualene cyclase (OSC), a key enzyme in the cholesterol synthetic pathway. It has demonstrated low-density lipoprotein (LDL) cholesterol-lowering activity comparable to the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor simvastatin. In preclinical studies, Ro 48-8071 has been shown to lower LDL cholesterol by approximately 40% in hamsters at a dose of 150 μg/kg without affecting high-density lipoprotein levels and without any sign of liver toxicity.
Used in Hepatology Research:
In the field of hepatology, Ro 48-8071 is utilized as an inhibitor of lanosterol synthase, which is involved in the synthesis of cholesterol. By inhibiting this enzyme, Ro 48-8071 can potentially be used to study the effects of cholesterol synthesis inhibition on liver function and disease progression, particularly in conditions such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
Used in Cellular and Molecular Biology Research:
Ro 48-8071 is also used as a research tool in cellular and molecular biology to investigate the role of oxidosqualene cyclase and cholesterol synthesis in various cellular processes. It can help researchers understand the underlying mechanisms of cholesterol synthesis and its impact on cell signaling, membrane dynamics, and other biological functions. Additionally, it can be employed to study the effects of cholesterol synthesis inhibition on cell proliferation, differentiation, and apoptosis.
Check Digit Verification of cas no
The CAS Registry Mumber 161582-11-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,5,8 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 161582-11:
(8*1)+(7*6)+(6*1)+(5*5)+(4*8)+(3*2)+(2*1)+(1*1)=122
122 % 10 = 2
So 161582-11-2 is a valid CAS Registry Number.
InChI:InChI=1/C23H27BrFNO2/c1-3-14-26(2)15-6-4-5-7-16-28-20-12-13-21(22(25)17-20)23(27)18-8-10-19(24)11-9-18/h3,8-13,17H,1,4-7,14-16H2,2H3
161582-11-2Relevant articles and documents
INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER
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, (2014/01/17)
Disclosed herein are methods and compositions related to the discovery that cholesterol inhibitors induce the anti-proliferative protein, estrogen receptor beta (ERβ), in both ERα- positive and ERα-negative breast cancer cell lines, including triple negat
