161798-02-3 Usage
Description
Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate is an organic compound with a complex chemical structure. It is characterized by its ester functional group, which is derived from the combination of the carboxylic acid group of 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid and the hydroxyl group of ethanol. Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate is known for its potential applications in various industries, particularly in the pharmaceutical sector.
Uses
Used in Pharmaceutical Industry:
Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate is used as an intermediate compound for the synthesis of Febuxostat (F229000), which is an antipodagrics. Febuxostat is a medication used to treat gout, a metabolic disorder characterized by the accumulation of uric acid in the body, leading to inflammation and severe pain in the joints. The compound plays a crucial role in the development of this medication, contributing to its efficacy in managing gout symptoms and reducing the risk of recurrent attacks.
Check Digit Verification of cas no
The CAS Registry Mumber 161798-02-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,7,9 and 8 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 161798-02:
(8*1)+(7*6)+(6*1)+(5*7)+(4*9)+(3*8)+(2*0)+(1*2)=153
153 % 10 = 3
So 161798-02-3 is a valid CAS Registry Number.
161798-02-3Relevant articles and documents
A practical oxidative conversion of aldehydes into N-chloroaldimines
Jin, Can,Wang, Feng,Sun, Bin,Zhuang, Xiaohui
, p. 547 - 551 (2018/11/27)
A novel method for the preparation of N-chloroaldimines from commonly available aromatic aldehydes has been developed. The reaction proceeded effectively by two steps: aldehydes were initially transformed into imines and then chloro-substitution with NaClO2 gave the N-chloroaldimines. This simple protocol allows for the preparation of a variety of aromatic N-chloroaldimines in moderate to excellent yields without the isolation of the imine intermediate. We also found that 3-nitrobenzaldehyde and 4-cyanobenzaldehyde were converted into the related benzonitrile directly under the standard conditions.
A NOVEL PROCESS FOR THE PREPARATION OF FEBUXOSTAT
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Page/Page column 14, (2015/02/25)
The present invention relates to a novel preparation method for 2-(3-cyano-4-isobutoxyphenyl)- 4-methyl-1,3-thiazole-5-carboxylic acid (Febuxostat) via novel and high yielded conversion of a formyl group in to a cyano group.
PROCESS FOR THE PREPARATION OF 2-ARYLTHIAZOLE DERIVATIVES
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Paragraph 0043, (2013/11/19)
The present invention relates an improved process for the preparation of 2-arylthiazole derivatives which are intermediates of Febuxostat and further conversion to Febuxostat or pharmaceutically acceptable salts thereof.