1618656-77-1

Basic information

• Product Name: 3-(4-nitro-3-(trifluoromethyl)phenyl)-2-phenyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole
• Synonyms: 3-(4-nitro-3-(trifluoromethyl)phenyl)-2-phenyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole
• CAS NO: 1618656-77-1
• Molecular Weight: 443.449
• Mol File: 1618656-77-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-nitro-3-(trifluoromethyl)phenyl)-2-phenyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-nitro-3-(trifluoromethyl)phenyl)-2-phenyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole(1618656-77-1)
• EPA Substance Registry System: 3-(4-nitro-3-(trifluoromethyl)phenyl)-2-phenyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole(1618656-77-1)

Safety Data

• Hazardous Substances Data: 1618656-77-1(Hazardous Substances Data)

Upstream product

• 25752-17-4 2-phenyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]-thiazole 
• 344-38-7 4-bromo-1-nitro-2-(trifluoromethyl)benzene 

Relevant articles and documents

Palladium-catalyzed microwave-assisted direct arylation of imidazo[2,1-b]thiazoles with aryl bromides: Synthesis and mechanistic study

A palladium-catalyzed direct C-H arylation of various imidazo[2,1-b] thiazoles with a range of aryl bromides under microwave irradiation is described. 6-Phenyl substituted imidazo[2,1-b]thiazoles could be regioselectively C-5 arylated using the developed protocol. The utility of this method enables the representative coupling product to be achieved by a sequential one-pot reaction. Density functional theory (DFT) calculations show that this arylation proceeds via a concerted metalation-deprotonation (CMD) pathway, which is in agreement with our experimental results. This work provides a convenient access to a variety of biologically active imidazo[2,1-b]thiazole derivatives. Also, it enriches the mechanism study of site-selective C-H arylation in fused heterocycles, and offers a valuable guide to design highly efficient catalytic systems for the preparation of similar compounds. the Partner Organisations 2014.