1619994-69-2 Usage
Description
BroMosporine, with the chemical formula 1619994-69-2, is a potent pan-Bromodomain (BRD) inhibitor. It has been found to reactivate HIV-1 replication in various latency models, making it a significant compound in the field of molecular biology and pharmaceutical research.
Uses
Used in Pharmaceutical Industry:
BroMosporine is used as a broad-spectrum inhibitor for bromodomains, which are protein domains that recognize and bind to acetylated lysine residues. This application is crucial in the development of targeted therapies for various diseases, as bromodomain inhibition can modulate gene expression and cellular processes.
Used in HIV Research and Treatment:
BroMosporine is used as a reactivating agent for HIV-1 replication in different latency models. This application is vital in the study of HIV latency and the development of strategies to combat the virus, as reactivating latent HIV reservoirs can help in the clearance of the virus from the body and contribute to the development of a potential cure for HIV.
References
1) Picaud?et al.?(2016),?Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia; Sci. Adv.?2?e1600760
2) Pan?et al.?(2017),?The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells; Oncotarget?8?94104
Check Digit Verification of cas no
The CAS Registry Mumber 1619994-69-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,9,9,9 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1619994-69:
(9*1)+(8*6)+(7*1)+(6*9)+(5*9)+(4*9)+(3*4)+(2*6)+(1*9)=232
232 % 10 = 2
So 1619994-69-2 is a valid CAS Registry Number.
