1620-55-9

Basic information

• Product Name: 1-PHENYL-2-PYRIDIN-4-YL-ETHANONE
• Synonyms: 1-PHENYL-2-PYRIDIN-4-YL-ETHANONE;1-Phenyl-2-(4-pyridinyl)-ethanone
• CAS NO: 1620-55-9
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.23254
• Mol File: 1620-55-9.mol
• Article Data: 31

Chemical Properties

• Melting Point: 100-105 °C
• Boiling Point: 350.3 °C at 760 mmHg
• Flash Point: 173.5 °C
• Appearance: /
• Density: 1.127 g/cm³
• Vapor Pressure: 4.44E-05mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 5.31±0.10(Predicted)
• CAS DataBase Reference: 1-PHENYL-2-PYRIDIN-4-YL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-2-PYRIDIN-4-YL-ETHANONE(1620-55-9)
• EPA Substance Registry System: 1-PHENYL-2-PYRIDIN-4-YL-ETHANONE(1620-55-9)

Safety Data

• Hazardous Substances Data: 1620-55-9(Hazardous Substances Data)

Usage

General Description

1-Phenyl-2-pyridin-4-yl-ethanone, also known as Acetylphenylpyridine, is a chemical compound with the molecular formula C15H13NO. It is a yellow crystalline powder with a molecular weight of 223.27 g/mol. 1-PHENYL-2-PYRIDIN-4-YL-ETHANONE is used in the synthesis of pharmaceutical drugs, agrochemicals, and other organic compounds. It is also utilized as a research chemical and as an intermediate in organic synthesis. Additionally, 1-Phenyl-2-pyridin-4-yl-ethanone has been studied for its potential pharmacological properties, including its effects on the central nervous system. However, it is important to handle this chemical with care as it may be hazardous if not properly managed.

InChI:InChI=1/C13H11NO/c15-13(12-4-2-1-3-5-12)10-11-6-8-14-9-7-11/h1-9H,10H2

Upstream product

• 108-89-4 picoline 
• 60-29-7 diethyl ether 
• 591-51-5 phenyllithium 
• 100-47-0 benzonitrile 
• 13295-94-8 4-(phenylethynyl)pyridine 
• 86123-36-6 benzoic acid-(1-phenyl-2-[4]pyridyl-vinyl ester) 
• 408320-71-8 4-(α-bromo-styryl)-pyridine 
• 174844-93-0 4-(2-bromo-2-phenylvinyl)pyridine 
• 98-88-4 benzoyl chloride 
• 109937-69-1 2-[1-(2,6-dichloro-benzyl)-1H-[4]pyridylidene]-1-phenyl-ethanone 
• 93-58-3 benzoic acid methyl ester 
• 1696-17-9 N,N-diethylbenzamide 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 98-86-2 acetophenone 

Downstream Products

• 35779-40-9 1-phenyl-2-(pyridin-4-yl)ethane-1,2-dione 
• 59576-22-6 2-(4-pyridinyl)-1-phenylethylamine 
• 99466-56-5 2-brom-2-(4-pyridyl)-1-phenyl-1-ethanon-hydrobromid 
• 59576-20-4 1-phenyl-2-[4]pyridyl-ethanone-(E)-oxime 
• 6312-22-7 1-phenyl-2-(pyridin-4-yl)propan-1-one 
• 120207-42-3 2-(1-phenacyl-1H-[4]pyridylidene)-1-phenyl-ethanone 
• 86123-36-6 benzoic acid-(1-phenyl-2-[4]pyridyl-vinyl ester) 
• 102478-85-3 2-[1-(β-hydroxy-phenethyl)-1H-[4]pyridylidene]-1-phenyl-ethanone 
• 20151-37-5 rac-1-phenyl-2-(4-pyridyl)ethanol 
• 1593235-49-4 C₁₄H₁₁N₃O 
• 1593235-45-0 4-(4,5-diphenyl-2-oxazolylmethyl)pyridine 
• 1007554-45-1 6-chloro-3-phenyl-4-(pyridin-4-yl)pyridazine 
• 1007554-44-0 6-phenyl-5-(pyridin-4-yl)pyridazin-3-ol 
• 1007554-43-9 6-phenyl-5-(pyridin-4-yl)-4,5-dihydropyridazin-3(2H)-one 

Relevant articles and documents

Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+System

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple methyl benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alcohol products. This finding greatly increases the practicality and impact of this chemistry. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib.

Highly efficient asymmetric bioreduction of 1-aryl-2-(azaaryl)ethanones. Chemoenzymatic synthesis of lanicemine

Different ketoreductases (KREDs) have been used to promote a highly selective reduction of several 1-aryl-2-(azaaryl)ethanones (azaaryl = pyridinyl, quinolin-2-yl), the corresponding secondary alcohols being obtained with very high yields and enantiomeric excesses (ee > 99%). The absolute configuration of each optically active alcohol has been assigned by means of modified Mosher and Kelly methods, two shielding effects being evaluated: (1) the Mosher phenyl ring effect on the azaaryl protons and (2) the one of the azaaryl ring on the Mosher methoxy group. In addition, the biologically active amine lanicemine has been synthesized from (R)-1-phenyl-2-(pyridin-2-yl)ethanol, thus proving the utility of the secondary alcohols here prepared.

Small molecule that reverses dexamethasone resistance in t-cell acute lymphoblastic leukemia (T-ALL)

Glucocorticoids are one of the most utilized and effective therapies in treating T-cell acute lymphoblastic leukemia. However, patients often develop resistance to glucocorticoids, rendering these therapies ineffective. We screened 9517 compounds, selected for their lead-like properties, chosen from among 3372615 compounds, against a dexamethasone-resistant T-ALL cell line to identify small molecules that reverse glucocorticoid resistance. We synthesized analogues of the most effective compound, termed J9, from the screen in order to define the scaffolds structure-activity relationship. Active compounds restored sensitivity to glucocorticoids through upregulation of the glucocorticoid receptor. This compound and mechanism may provide a strategy for overcoming glucocorticoid resistance in patients with T-ALL.