162012-30-8

Basic information

• Product Name: 2(5H)-Furanone, 4-[4-(methylthio)phenyl]-3-phenyl-
• Synonyms: 4-(4-methylthiophenyl)-4-pheny-2(5H)-furanone;4-(4-methylthiophenyl)-3-phenyl-2(5H)-furanone;4-(4-(methylthio)phenyl)-3-phenylfuran-2(5H)-one;2(5H)-Furanone,4-[4-(methylthio)phenyl]-3-phenyl;3-Phenyl-4-(4-(methylthio)phenyl)-2-(5H)-furanone;4-(4-METHYLSULFANYL-PHENYL)-3-PHENYL-5H-FURAN-2-ONE;3-(4-methylsulfanyl-phenyl)-2-phenyl-2-buten-4-olide;4-(4'-methylthiophenyl)-3-phenyl-5H-furan-2-one
• CAS NO: 162012-30-8
• Molecular Formula: C17H14O2S
• Molecular Weight: 282.363
• Mol File: 162012-30-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2(5H)-Furanone, 4-[4-(methylthio)phenyl]-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5H)-Furanone, 4-[4-(methylthio)phenyl]-3-phenyl-(162012-30-8)
• EPA Substance Registry System: 2(5H)-Furanone, 4-[4-(methylthio)phenyl]-3-phenyl-(162012-30-8)

Safety Data

• Hazardous Substances Data: 162012-30-8(Hazardous Substances Data)

Upstream product

• 960-16-7 tributylphenylstannane 
• 487047-30-3 3-chloro-4-(4'-methylthiophenyl)-5H-furan-2-one 
• 1778-09-2 4-(Methylthio)acetophenone 
• 103-82-2 phenylacetic acid 
• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 
• 108154-63-8 3-Phenyl-4-p-bromophenyl-2(5H)-furanone 
• 108154-64-9 3-Phenyl-4-p-chlorophenyl-2(5H)-furanone 
• 210292-04-9 (4-methylsulfanylphenyl)magnesium chloride 
• 98546-51-1 (4-thiomethoxyphenyl)boronic acid 
• 98-80-6 phenylboronic acid 
• 329328-49-6 3-bromo-4-(4'-methylthiophenyl)-5H-furan-2-one 
• 124-38-9 carbon dioxide 

Downstream Products

• 1378303-49-1 C₂₃H₂₀N₂O₂S 
• 1378303-48-0 sulfiliminium mesitylenesulfonate salt 
• 866336-10-9 thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester 
• 745820-44-4 4-(4-(methylsulfinyl)phenyl)-3-phenylfuran-2(5H)-one 
• 162011-90-7 rofecoxib 

Relevant articles and documents

PURIFIED FORMS OF ROFECOXIB, METHODS OF MANUFACTURE AND USE

The subject matter disclosed herein relates to rofecoxib, also known as TRM-201 or RXB-201, its method of manufacture, and use. In certain aspects, the highly pure or substantially pure rofecoxib as provided herein has a favorable purity profile and is the active ingredient in a pharmaceutical composition that is administered to treat or prevent a number of conditions, including pain associated with a condition caused by a bleeding disorder.

Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx and Arcoxia

The preparation of the sulfoxide analogues 2 and 4, and their enantiomeric pure forms is discussed as well as their potential to act as prodrugs to the potent and selective sulfone-containing COX-2 inhibitors rofecoxib and etoricoxib. Sulfoxides 2 and 4 w

A general method for the synthesis of aryl [11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression

A general one-pot method has been developed for the conversion of an aryl thiol moiety masked as the butyrate ester to the corresponding 11C-labeled methylsulfone group. The potential of this methodology has been demonstrated by the successful radiosynthesis of carbon-11 analogues of several highly selective cyclooxygenase-2 (COX-2) inhibitors such as Rofecoxib, Etoricoxib, and 3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethyl isoxazole in high yield. The chemical and radiochemical purities obtained for the 11C-labeled COX-2 inhibitors are >99% with a specific activity >1000 Ci/mmol.