1622-61-3 Usage
Description
Clonazepam is a first-generation antiepileptic drug (AED) belonging to the benzodiazepine class. It is known under the proprietary brand names Rivotril (Roche, Basel) in the UK and Klonopin (Roche, Basel) in the USA. Clonazepam is characterized by its antiepileptic, anxiolytic, and antimanic properties, as well as its anticonvulsant effects. It is used in the treatment of various types of epilepsy, seizures, myoclonus, and associated abnormal movements, as well as panic disorders. However, its use can be limited by the development of tolerance and sedation. Clonazepam is regulated as a Schedule IV compound in the United States and is a controlled substance (depressant).
Uses
Used in Pharmaceutical Industry:
Clonazepam is used as an antiepileptic agent for the treatment of absence seizures and myoclonic seizures. It is effective in managing various types of epilepsy and seizures, as well as myoclonus and associated abnormal movements.
Used in Psychiatry:
Clonazepam is used as an anxiolytic and antimanic agent for the treatment of panic disorders and other anxiety-related conditions. Its anxiolytic properties help in alleviating symptoms of anxiety and panic attacks.
Used in Research and Forensic Applications:
Clonazepam, as an analytical reference material, is used in research and forensic applications due to its classification as a benzodiazepine and its regulation as a Schedule IV compound in the United States.
Chemical Properties:
Clonazepam is a tan solid with the chemical formula ChEBI: 1,3-Dihydro-2H-1,4-benzodiazepin-2-one, in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively.
Brand Name:
The brand name for Clonazepam is Klonopin (Roche).
Generic formulation
MHRA/ CHM advice to minimize risk when switching patients with epilepsy between different manufacturers’ products (including generic products):
The need for continued supply of a particular manufacturer’s product should be based on clinical judgment, and consultation with the patient and/ or carer, taking into account factors such as seizure frequency and treatment history.
Indications
Epilepsy: monotherapy and adjunctive therapy of focal and generalized seizures. Recommendations summarized from NICE (2012)
Seizure types: on referral to tertiary care (absence seizures, myoclonic seizures).
Epilepsy types: on referral to tertiary care (absence syndromes, juvenile myoclonic epilepsy, idiopathic generalized epilepsy).
Dose titration
Epilepsy: 1 mg nocte for 4 days, then increased over 2– 4 weeks; usual maintenance dose 4–8 mg nocte or divided into 3 or 4 doses.
Cautions
Patients with depression/ suicidal ideation.
Patients with brain damage.
Patients with cerebellar/ spinal ataxia.
Patients with acute porphyrias.
Patients with airways obstruction.
Interactions
With AEDs
Plasma concentration of clonazepam can be reduced by carbamazepine, phenobarbital, phenytoin, and primidone.
With other drugs
Plasma concentration of clonazepam is decreased by rifampicin and can be reduced by theophylline.
Plasma concentration of clonazepam is increased by cimetidine, disulfiram, fluvoxamine, and ritonavir
There is an increased risk of prolonged sedation and respiratory depression when clonazepam is given with amprenavir.
There are enhanced hypotensive and sedative effects when clonazepam is given with alpha- blockers or moxonidine.
There is an enhanced hypotensive effect when clonazepam is given with ACE inhibitors, adrenergic neurone blockers, angiotensin- II receptor antagonists, beta- blockers, calcium channel blockers, clonidine, diazoxide, diuretics, hydralazine, methyldopa, minoxidil, nitrates, or nitroprusside.
There is an increased sedative effect when clonazepam is given with general anaesthetics, tricyclic antidepressants, antihistamines, antipsychotics, baclofen, lofexidine, mirtazapine, nabilone, opioid analgesics, tizanidine.
Clonazepam may possibly antagonize the effects of levodopa.
Special populations
Hepatic impairment
Start with smaller initial dose or reduce maintenance dose.
Avoid in severe impairment.
Renal impairment
Start with smaller dose in significant impairment.
Pregnancy
As a precautionary measure, it is preferable to avoid the use of clonazepam and clobazam during pregnancy. Clonazepam and clobazam should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.
Administration of clonazepam in the last trimester of pregnancy or during labour can result in hypothermia, hypotonia, respiratory depression, and feeding difficulties in the neonate.
Infants born to mothers who have taken clonazepam during the later stages of pregnancy may develop physical dependence, and may be at risk for developing withdrawal symptoms in the postnatal period.
Clonazepam, like all benzodiazepines, are present in milk and should be avoided if possible during breastfeeding.
Behavioural and cognitive effects in patients with epilepsy
Behavioural effects include sleepiness, poor coordination, and agitation with paradoxical aggression/ disinhibition (usually dose- dependent). Long- term use may result in tolerance, dependence, and withdrawal symptoms if stopped abruptly. In addition to seizure exacerbation, abrupt discontinuation of benzodiazepines can be accompanied by changes in mental status, including anxiety, agitation, confusion, depression, psychosis, and delirium. Dependence occurs in one- third of patients who take clonazepam for longer than 4 weeks. Moreover, clonazepam may aggravate symptoms in patients who are depressed. Benzodiazepines are more frequently associated with adverse cognitive effects than most other AEDs. Among these, anterograde amnesia has been reported in patients treated with clonazepam (mainly at high doses).
Psychiatric use
Clonazepam has been found to be effective in the short- term treatment of anxiety disorders, including generalized anxiety disorder, social phobia, and panic disorder. Catatonia, alcohol withdrawal, and insomnia are other common indications supported by evidence. Clonazepam is also sometimes used for the treatment of acute mania, or psychosis- induced aggression and agitation (adjunctive treatment for bipolar disorder and schizophrenia).
Originator
Rivotril,Roche,France,1973
Manufacturing Process
The following description is taken from US Patent 3,116,203. A stirred solution
of 75 g of 2-amino-2'-nitrobenzophenone in 700 ml of hot concentrated
hydrochloric acid was cooled to 0°C and a solution of 21.5 g of sodium nitrite
in 50 ml of water was added in the course of 3 hours. The temperature of the
suspension was kept at 2° to 7°C during the addition. The resulting clear
solution was poured into a stirred solution of 37 g of cuprous chloride in 350
ml of hydrochloric acid 1:1. The solid which had formed after a few minutes
was filtered off, washed with water and recrystallized from ethanol. Crystals of
2-chloro-2'-nitrobenzophenone melting at 76° to 79°C were obtained.
A solution of 20 g of 2-chloro-2'-nitrobenzophenone in 450 ml of ethanol was
hydrogenated at normal pressure and room temperature with Raney nickel.
After uptake of about 6 liters of hydrogen the catalyst was filtered off, and the
alcohol then removed in vacuo. The residue was distilled in a bulb tube at 0.4
mm and a bath temperature of 150° to 165°C giving a yellow oil. The oil was
dissolved in alcohol, and on addition of water, needles of 2-amino-2'-
chlorobenzophenone melting at 58° to 60°C were obtained.
To a solution of 42 g of 2-amino-2'-chlorobenzophenone in 500 ml of benzene,
19 ml of bromoacetyl bromide was added dropwise. After refluxing for 2
hours, the solution was cooled, washed with 2 N sodium hydroxide and
evaporated. The residue was recrystallized from methanol giving crystals of 2-
bromo-2'-(2-chlorobenzoyl)acetanilide melting at 119° to 121°C.To a solution of 14.5 g of 2-bromo-2'-(2-chlorobenzoyl)acetanilide in 100 ml
of tetrahydrofuran, an excess of liquid ammonia (ca 150 ml) was added. The
ammonia was kept refluxing with a dry-ice condenser for 3 hours after which
time the ammonia was allowed to evaporate and the solution was poured into
water. Crystals of 2-amino-2'-(2-chlorobenzoyl)acetanilide were collected,
which after recrystallization from ethanol melted at 162° to 164°C.
A solution of 3 g of 2-amino-2'-(2-chlorobenzoyl)acetanilide in 50 ml of
pyridine was refluxed for 24 hours after which time the pyridine was removed
in vacuo. The residue was recrystallized from methanol and a mixture of
dichloromethane and ether giving crystals of 5-(2-chlorophenyl)-3H-1,4-
benzodiazepin-2(1H)-one melting at 212° to 213°C.
To a solution of 13.5 g of 5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one
in 60 ml of concentrated sulfuric acid, a solution of 5.5 g of potassium nitrate
in 20 ml concentrated sulfuric acid was added dropwise. The solution then was
heated in a bath at 45° to 50°C for 2.5 hours, cooled and poured on ice. After
neutralizing with ammonia, the formed precipitate was filtered off and boiled
with ethanol. A small amount of white insoluble material was then filtered off.
The alcoholic solution on concentration yielded crystals of 7-nitro-5-(2-
chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one which, after recrystallization
from dichloromethane, melted at 238° to 240°C.
Therapeutic Function
Anticonvulsant
Hazard
Moderately toxic.
Clinical Use
Benzodiazepine:
Anticonvulsant
Anxiolytic
Restless leg syndrome
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: metabolism possibly increased by
rifampicin.
Antipsychotics: increased sedative effects; increased
risk of hypotension, bradycardia and respiratory
depression with parenteral clonazepam and IM
olanzapine; risk of serious adverse effects in
combination with clozapine.
Antivirals: concentration possibly increased by
ritonavir.
Disulfiram: metabolism inhibited, increased sedative
effects.
Sodium oxybate: enhanced effects of sodium oxybate
- avoid.
Metabolism
Clonazepam is extensively metabolised in the liver, its
principal metabolite being 7-aminoclonazepam, which
has no antiepileptic activity; minor metabolites are the
7-acetamido- and 3-hydroxy-derivatives.
It is excreted mainly in the urine almost entirely as its
metabolites in free or conjugated form.
Check Digit Verification of cas no
The CAS Registry Mumber 1622-61-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,2 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1622-61:
(6*1)+(5*6)+(4*2)+(3*2)+(2*6)+(1*1)=63
63 % 10 = 3
So 1622-61-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)
1622-61-3Relevant articles and documents
Method for synthesizing clonazepam compound
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, (2021/07/24)
The invention discloses a method for synthesizing a clonazepam compound, and belongs to the technical field of organic chemical synthesis, and the preparation method comprises the following steps: by taking 2-amino-4-nitrophenyl potassium trifluoroborate as an initial raw material, carrying out oxidative coupling, amidation, affinity substitution reaction, intramolecular condensation reaction and the like to obtain a target compound; the method disclosed by the invention is short in synthesis step, safe to operate and simple and convenient in post-treatment, and the product can be obtained by directly filtering and leaching without other purification; only conventional acid, alkali and solvents are used in the whole reaction process, the cost is low, and the yield is increased by 30% or above.
Novel method for preparing 7-amino clonazepam compound
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Paragraph 0042-0043; 0059-0061, (2021/07/08)
The invention discloses a novel method for preparing a 7-amino clonazepam compound, and belongs to the technical field of organic synthesis. The preparation method comprises the steps that 2-amino-4-nitrobenzoic acid serves as an initial raw material, and a target compound is obtained through the processes of acetyl-lactonization, Grignard reaction, amide hydrolysis, intramolecular condensation reaction, reduction and the like. The method provided by the invention is safe to operate, avoids the use of heavy metals, is simple and convenient in post-treatment, can obtain the product through direct filtration and recrystallization, and does not need other purification. Only conventional acid, alkali and solvents are used in the whole reaction process, so that the method is less in environmental pollution, low in cost and higher in yield.
On the synthesis of 3-amino-4-aryl-2(1H)-quinolinones
Bahr,Usbeck
, p. 668 - 671 (2007/10/02)
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