16222-29-0Relevant articles and documents
Production of aminophenols
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, (2008/06/13)
A method of producing N,N-disubstituted aminophenols of the general formula STR1 wherein R1 and R2 are the same or different and each represents a saturated or unsaturated aliphatic hydrocarbyl, cycloalkyl, aralkyl, the phenyl ring of which may be further substituted, alkoxyalkyl, or a cycloalkylalkyl, except that R1 and R2 are not simultaneously methyl and R' represents hydrogen, halogen, nitro, cyano, alkyl or alkoxy, which comprises reacting an aminophenol of general formula STR2 wherein R3 represents hydrogen or R1, and R' is as defined above, with an organic halide species of general formula R2 X wherein R2 is as defined above and X is halogen under aqueous acidic conditions with the periodic addition of an acid trapping agent in such a way that continuous monitoring of pH is not required.