162267-01-8

Basic information

• Product Name: 1-(4-(methylthio)phenyl)butan-1-one
• Synonyms: 1-(4-(methylthio)phenyl)butan-1-one
• CAS NO: 162267-01-8
• Molecular Weight: 194.298
• Mol File: 162267-01-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-(methylthio)phenyl)butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(methylthio)phenyl)butan-1-one(162267-01-8)
• EPA Substance Registry System: 1-(4-(methylthio)phenyl)butan-1-one(162267-01-8)

Safety Data

• Hazardous Substances Data: 162267-01-8(Hazardous Substances Data)

Upstream product

• 557-93-7 2-bromoprop-1-ene 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 100-68-5 methyl-phenyl-thioether 
• 141-75-3 butyryl chloride 

Downstream Products

• 90819-57-1 4-butyrylbenzonitrile 
• 760948-50-3 1-(4-(methylsulfonyl)phenyl)butan-1-one 

Relevant articles and documents

Nickel-Catalyzed Cyanation of Aryl Thioethers

A nickel-catalyzed cyanation of aryl thioethers using Zn(CN)2 as a cyanide source has been developed to access functionalized aryl nitriles. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) in combination with the base KOAc (potassium acetate) is essential for achieving this transformation efficiently. This reaction involves both a C-S bond activation and a C-C bond formation. The scalability, low catalyst and reagents loadings, and high functional group tolerance have enabled both late-stage derivatization and polymer recycling, demonstrating the reaction's utility across organic chemistry.