1622923-64-1 Usage
Description
Potassium 3-thiophenoyltrifluoroborate (KAT) is a stable reagent derived from acyltrifluroborates, characterized by its bench, air, and moisture stability. It is primarily utilized in the formation of amide bonds with hydroxylamines, showcasing its versatility in chemical reactions. The unique properties of KAT allow for rapid and chemoselective amide bond formations, making it a valuable compound in the field of chemistry.
Uses
Used in Chemical Synthesis:
Potassium 3-thiophenoyltrifluoroborate is used as a reagent for rapid and chemoselective amide bond formations with hydroxylamines. Its application is significant due to its stability and the fact that it allows these reactions to proceed under aqueous conditions without the need for coupling reagents or protecting groups.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, potassium 3-thiophenoyltrifluoroborate is used as a key component in the synthesis of various drugs and drug candidates. Its ability to form amide bonds quickly and selectively makes it a valuable tool in the development of new medications and the improvement of existing ones.
Used in Research and Development:
Potassium 3-thiophenoyltrifluoroborate is also used as a research tool in academic and industrial laboratories. Its stability and reactivity make it an ideal compound for exploring new chemical reactions and developing innovative synthetic methods.
Check Digit Verification of cas no
The CAS Registry Mumber 1622923-64-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,2,9,2 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1622923-64:
(9*1)+(8*6)+(7*2)+(6*2)+(5*9)+(4*2)+(3*3)+(2*6)+(1*4)=161
161 % 10 = 1
So 1622923-64-1 is a valid CAS Registry Number.
1622923-64-1Relevant articles and documents
Catalytic Synthesis of Potassium Acyltrifluoroborates (KATs) from Boronic Acids and the Thioimidate KAT Transfer Reagent
Schuhmacher, Anne,Ryan, Sarah J.,Bode, Jeffrey W.
supporting information, p. 3918 - 3922 (2020/12/23)
We report the synthesis of potassium acyltrifluoroborates (KATs) by a palladium-catalyzed cross-coupling of boronic acids and the thioimidate KAT transfer reagent. The combination of widely available aryl- and vinylboronic acids with commercially available thioimidate 1 using catalytic PdII and a CuII additive enables the preparation of KATs in high yields and with good functional group tolerance. This formal insertion of CO into organoboronic acids can also be applied to boronic acid pinacol esters and potassium organotrifluoroborates using a slightly modified procedure. The cross-coupling can be telescoped into the one-pot synthesis of amides and α-aminotrifluoroborates by exploiting the unique chemistry of KATs and their trifluoroborate iminium (TIM) derivatives.
