1629-26-1

Basic information

• Product Name: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-
• Synonyms: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-;2-(4-Fluoro-phenyl)-benzothiazole;2-(4-fluorophenyl)-1,3-benzothiazole
• CAS NO: 1629-26-1
• Molecular Formula: C₁₃H₈FNS
• Molecular Weight: 229.2727232
• Mol File: 1629-26-1.mol
• Article Data: 172

Chemical Properties

• Boiling Point: 352.1 °C at 760mmHg
• Flash Point: 166.7 °C
• Appearance: /
• Density: 1.304 g/cm³
• CAS DataBase Reference: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-(1629-26-1)
• EPA Substance Registry System: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-(1629-26-1)

Safety Data

• Hazardous Substances Data: 1629-26-1(Hazardous Substances Data)

Usage

General Description

Benzothiazole, 2-(4-fluorophenyl)- is a chemical compound with the molecular formula C14H9FNS. It is a heterocyclic organic compound that is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Benzothiazole derivatives have been studied for their potential antitumor, antiviral, and antimicrobial activities. The presence of a fluorine substituent on the phenyl ring of benzothiazole can greatly influence its physicochemical and biological properties, making it a valuable building block for the development of new drugs and materials. Furthermore, 2-(4-fluorophenyl)benzothiazole has also found application in the field of organic electronics as a component in the fabrication of organic light-emitting diodes and organic photovoltaic devices.

Upstream product

• 2516-40-7 2-bromo-1,3-benzothiazole 
• 1765-93-1 4-fluoroboronic acid 
• 95-16-9 1,3-Benzothiazole 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 456-22-4 4-Fluorobenzoic acid 
• 1246887-36-4 N-(2-bromophenyl)-4-fluorobenzothioamide 
• 1629-22-7 2-Chlor-N-(4-fluor-thiobenzoyl)-anilin 
• 1194-02-1 4-fluorobenzonitrile 
• 137-07-5 2-amino-benzenethiol 
• 403-43-0 4-fluorobenzoyl chloride 
• 62-53-3 aniline 
• 140-75-0 para-fluorobenzylamine 
• 824-75-9 p-fluorobenzamide 
• 402-42-6 4-fluoro-1-trichloromethylbenzene 

Downstream Products

• 940287-58-1 2-(4-fluoro-2-nitrophenyl)benzo[d]thiazole 

Relevant articles and documents

Orange phosphorescent Ir(III) complexes consisting of substituted 2-phenylbenzothiazole for solution-processed organic light-emitting diodes

Orange phosphorescent iridium(III) complexes, (DMBT)2Ir(acac) and (TBT)2Ir(acac), based on either 2-(3,4-dimethylphenyl)benzo[d]thiazole (DMBT) or 2-(4-(trimethylsilyl)phenyl)benzo[d]thiazole (TBT) as the cyclometalated main ligands

Microwave-induced solvent-free synthesis of 2-arylbenzothiazoles using p-TsOH

A simple and efficient procedure has been developed for the synthesis of 2-arylbenzothiazoles by a one-pot reaction of o-aminothiophenol with β-chlorocinnamaldehydes using p-TsOH under microwave irradiation.

Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted sele

Heterocyclic reaction inducted by Br?nsted–Lewis dual acidic Hf-MOF under microwave irradiation

Use of green chemistry and alternative strategies has been explored to prepare diverse organic derivatives. The combination between heterogeneous catalyst, environmentally benign reaction and high-yielding methods is gaining momentum. Herein, a defective 6-connected Hf-MOF, named Hf-BTC, was efficiently synthesized and characterized for the heterogeneous catalysis under microwave irradiation. The MOF features including structural defect, porosity, acidity, and stability was analyzed by powder X-ray diffraction, N2 sorption isotherms, acid-base titration, and thermal gravimetric analysis. In the catalytic studies, the Br?nsted-Lewis dual acidic Hf-BTC was efficiently applied for the synthesis of the heterocyclic compounds via the microwave-assisted cycloaddition and condensation reactions. The reactions proceeded smoothly in the presence of the Hf-MOF with a broad scope of substrates provided the expected products in high to excellent yields (up to 99 %) for few minutes and the catalyst could be easily recycle over many consecutive reactions without loss of its reactivity and structure.

Sulfur-Promoted Redox Cyclization of 2,2′-Dinitrodiphenyl Disulfides and Benzylamines

This study aims to develop green and sustainable advanced synthetic methods based on redox cyclization. Elemental sulfur is shown to promote the efficient synthesis of 2-substituted benzothiazoles from 2,2′-dinitrodiphenyl disulfides and benzylamines via redox cyclization in the absence of transition-metal catalysts and solvents. The 2-substituted benzothiazoles are obtained in good to excellent yields. This synthetic methodology is highly atom-economical and does not require any external oxidizing and/or reducing agents.