163152-10-1

Basic information

• Product Name: 2-(chloroacetoxymethyl)benzoic acid
• Synonyms: 2-(chloroacetoxymethyl)benzoic acid
• CAS NO: 163152-10-1
• Molecular Weight: 228.632
• Mol File: 163152-10-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(chloroacetoxymethyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(chloroacetoxymethyl)benzoic acid(163152-10-1)
• EPA Substance Registry System: 2-(chloroacetoxymethyl)benzoic acid(163152-10-1)

Safety Data

• Hazardous Substances Data: 163152-10-1(Hazardous Substances Data)

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 612-20-4 2-(hydroxymethyl)benzoic acid 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 171079-93-9 2-[2-(2-Chloro-acetoxy)-ethyl]-benzoic acid 
• 163152-12-3 1,3,4,6-tetra-O-acetyl-2-O-<2-(chloroacetoxymethyl)benzoyl>-α-D-galactopyranose 
• 163152-11-2 1,3,4,6-tetra-O-acetyl-2-O-<2-(chloroacetoxymethyl)benzoyl>-α-D-glucopyranose 
• 163152-15-6 3,4,6-tri-O-acetyl-2-O-<2-(chloroacetoxymethyl)benzoyl>-α-D-galactopyranosyl bromide 
• 163152-14-5 3,4,6-tri-O-acetyl-2-O-<2-(chloroacetoxymethyl)benzoyl>-α-D-glucopyranosyl bromide 
• 163152-25-8 O-<3,4,6-tri-O-acetyl-2-O-<2-(chloroacetoxymethyl)benzoyl>-β-D-glucopyranosyl>-(1->2)-1,3,4,6-tetra-O-acetyl-α-D-glucopyranose 
• 163152-19-0 2-benzoyloxyethyl 3,4,6-tri-O-acetyl-2-<2-(chloroacetoxymethyl)benzoylamido>-2-deoxy-β-D-glucopyranoside 
• 163152-13-4 1,3,4,6-tetra-O-acetyl-2-<2-(chloroacetoxymethyl)benzoylamido>-2-deoxy-β-D-glucopyranose 
• 163152-09-8 2-(chloroacetoxymethyl)benzoyl chloride 

Relevant articles and documents

A chloroacetate based ratiometric fluorescent probe for cysteine detection in biosystems

The specific detection of cysteine (Cys) over homocysteine (Hcy), glutathione (GSH) and other amino acids is of great significance for studying its biological functions as well as for the diagnosis of related diseases. Chloroacetyl group was often used as a reaction site for cysteine fluorescent probes for its sensitivity and selectivity. However, high background fluorescence and low stability are common problems encountered by such probes. Here, four chloroacetyl group based fluorescent probes (C1, C2, C3, and H4) was synthesized for a comparative study. We found that the inefficient quenching ability of chloroacetyl group turned into an advantage when connected with a ratiometric fluorophore. With the modification of chloroacetyl group, probe H4 displayed excellent ratiometric property and great selectivity for Cys, the stability was also improved. Additionally, the probe was successfully applied for quantitative detection of Cys in fetal bovine serum and real-time imaging in living HeLa cells with low toxicity.