163759-94-2

Basic information

• Product Name: N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
• Synonyms: N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite;Cytidine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-(2-Methoxyethyl)-5-Methyl-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite];N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];2'-O-MOE-5Me-C(Bz)-3'-phosphoramidite;N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl diisopropylphosphoramidite);N4-Bz-5'-O-DMTr-2'-O-(2-methoxyethyl)-5-methylcytidine-3'-CED-phosphoramidite;N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite
• CAS NO: 163759-94-2
• Molecular Formula: C47H54N5O9P
• Molecular Weight: 863.933521
• Mol File: 163759-94-2.mol
• Article Data: 89

Chemical Properties

• Appearance: White to Off-white/Powder
• PKA: 8.59±0.40(Predicted)
• CAS DataBase Reference: N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite(163759-94-2)
• EPA Substance Registry System: N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite(163759-94-2)

Safety Data

• Hazardous Substances Data: 163759-94-2(Hazardous Substances Data)

Usage

Description

N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite is a nucleotide derivative that plays a crucial role in the stereoselective synthesis of nucleoside alkyl-phosphonates. N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite is characterized by its unique structure, which includes a benzoyl group at the N4 position, a DMT (dimethoxytrityl) group at the 5' position, a methyl group at the 2' position, and a 3'-CE (3'-cyanoethyl) phosphoramidite group. These structural features contribute to its reactivity and selectivity in chemical reactions, making it a valuable building block for the synthesis of various nucleoside analogs and their derivatives.

Uses

Used in Pharmaceutical Industry:
N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite is used as a key intermediate in the synthesis of nucleoside analogs for pharmaceutical applications. These nucleoside analogs have the potential to be developed into antiviral, anticancer, and immunosuppressive drugs due to their ability to interfere with nucleic acid synthesis and function in target cells.
Used in Chemical Research:
In the field of chemical research, N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite serves as a valuable tool for studying the structure-activity relationships of nucleoside analogs. By incorporating this compound into various nucleoside derivatives, researchers can investigate the effects of different structural modifications on the biological activity and selectivity of these compounds.
Used in Nucleic Acid Synthesis:
N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite is also used in the synthesis of modified nucleic acids, such as oligonucleotides and aptamers, for applications in molecular biology and biotechnology. These modified nucleic acids can be used as probes, primers, or inhibitors in various assays and techniques, including PCR, sequencing, and gene regulation.

Upstream product

• 182496-01-1 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N₄-benzoyl-5-methylcytidine 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 
• 182496-00-0 2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methylcytidine 
• 93183-36-9 N,N-diisopropylamine tetrazolide 
• 133485-25-3 bis(diisopropylamino)(2-cyanoethoxy)phosphane 
• 93-97-0 benzoic acid anhydride 
• 253156-63-7 2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methylcytidine 
• 292037-80-0 N⁴-benzoyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methylcytidine 
• 22423-26-3 O-2,2'-cyclo-5-methyluridine 
• 163759-50-0 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-5-methyluridine 
• 163759-49-7 2'-O-(2-methoxyethyl)-5-methyluridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Relevant articles and documents

METHODS FOR THE PREVENTION AND TREATMENT OF MAJOR ADVERSE CARDIOVASCULAR EVENTS USING COMPOUNDS THAT MODULATE APOLIPOPROTEIN B

Provided herein, for example, are methods generally relating to preventing, treating and/or managing a major adverse cardiovascular event in a subject with a disease or condition at risk for a major adverse cardiovascular event, e.g., familial hypercholesterolemia. Also provided herein are methods relating to administering to the patient a therapeutically effective amount of an antisense oligonucleotide having a nucleobase SEQ ID NO: 247 (e.g., mipomersen).

Modulation of DC-SIGN expression

Compounds, compositions and methods are provided for modulating the expression of DC-SIGN. The compositions comprise oligonucleotides, targeted to nucleic acid encoding DC-SIGN. Methods of using these compounds for modulation of DC-SIGN expression and for diagnosis and treatment of diseases and conditions associated with expression of DC-SIGN are provided.

Antisense inhibition via RNAse H-independent reduction in mRNA

The present invention provides compositions and methods for reducing levels of a preselected mRNA, using antisense compounds targeted to a splice site or a region up to 50 nucleobases upstream of an exon/intron junction on said mRNA. Preferably, said antisense compounds do not elicit RNAse H cleavage of the mRNA.