1638211-04-7

Basic information

• Product Name: ML₃₀₃
• CAS NO: 1638211-04-7
• Molecular Weight: 399.372
• Mol File: 1638211-04-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ML₃₀₃(CAS DataBase Reference)
• NIST Chemistry Reference: ML₃₀₃(1638211-04-7)
• EPA Substance Registry System: ML₃₀₃(1638211-04-7)

Safety Data

• Hazardous Substances Data: 1638211-04-7(Hazardous Substances Data)

Upstream product

• 182344-21-4 (4-hydroxy-3-methoxyphenyl)boronic acid 
• 205127-44-2 5-methyl-2-(4-trifluoromethylphenyl)-2H-pyrazol-3-ylamine 
• 368-90-1 4-(trifluoromethyl)phenylhydrazine 

Relevant articles and documents

Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists

Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34 replication in MDCK cells, rescue MDCK cells from cytopathic effects of seasonal influenza A strains, reverse NS1-dependent inhibition of IFN-β gene expression, and suppress the slow growth phenotype in NS1-expressing yeast. These pyrazolopyridines will enable researchers to investigate NS1 function during infection and how antagonists can be utilized in the next generation of treatments for influenza infection.