1646-27-1

Basic information

• Product Name: METHYL 1-BENZOFURAN-2-CARBOXYLATE
• Synonyms: METHYL 1-BENZOFURAN-2-CARBOXYLATE;AKOS 91693;RARECHEM AL BF 0556;METHYL BENZOFURAN-2-CARBOXYLATE;Methyl 1-benzofuran-2-carboxylate, 2-(Methoxycarbonyl)-1-benzofuran, 2-(Methoxycarbonyl)benzo[b]furan;Methyl benzo[b]furan-2-carboxylate
• CAS NO: 1646-27-1
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.17
• Mol File: 1646-27-1.mol
• Article Data: 28

Chemical Properties

• Melting Point: 54-55 °C
• Boiling Point: 257.7°Cat760mmHg
• Flash Point: 109.7°C
• Appearance: /
• Density: 1.221g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 1-BENZOFURAN-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1-BENZOFURAN-2-CARBOXYLATE(1646-27-1)
• EPA Substance Registry System: METHYL 1-BENZOFURAN-2-CARBOXYLATE(1646-27-1)

Safety Data

• Hazardous Substances Data: 1646-27-1(Hazardous Substances Data)

Usage

Description

METHYL 1-BENZOFURAN-2-CARBOXYLATE is a chemical compound with the molecular formula C11H8O3. It is an ester derivative of benzofuran carboxylic acid and methyl alcohol, commonly utilized in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical drugs. Additionally, it is used in organic synthesis and as a research chemical, with potential applications in drug discovery and development, as well as in the production of fine chemicals. Due to its potentially harmful effects when handled improperly, it is important to exercise caution and use appropriate safety measures.

Uses

Used in Pharmaceutical Industry:
METHYL 1-BENZOFURAN-2-CARBOXYLATE is used as a building block for the synthesis of various pharmaceutical drugs, contributing to the development of new medications and therapies.
Used in Organic Synthesis:
METHYL 1-BENZOFURAN-2-CARBOXYLATE is employed in organic synthesis processes, where it serves as a key intermediate for creating more complex organic molecules.
Used in Research Chemicals:
METHYL 1-BENZOFURAN-2-CARBOXYLATE is used as a research chemical, aiding scientists in studying its properties and potential applications in various fields.
Used in Drug Discovery and Development:
METHYL 1-BENZOFURAN-2-CARBOXYLATE holds potential in drug discovery and development, where it may contribute to the creation of novel drugs and therapeutic agents.
Used in Production of Fine Chemicals:
METHYL 1-BENZOFURAN-2-CARBOXYLATE is utilized in the production of fine chemicals, which are important in various industries such as pharmaceuticals, agriculture, and fragrances.

Upstream product

• 67-56-1 methanol 
• 496-41-3 Benzofuran-2-carboxylic acid 
• 102452-20-0 benzofuran-2-yl-phenyl ketone-[(Z)-O-(toluene-4-sulfonyl)-oxime ] 
• 186581-53-3 diazomethane 
• 40359-34-0 methyl o-formylphenoxyacetate 
• 6280-80-4 2-Formylphenoxyacetic acid 
• 1874-23-3 methyl 5-nitrofuran-2-carboxylate 
• 1002130-71-3 methyl 3-[2-(methoxymethoxy)phenyl]propiolate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 4265-16-1 2-formylbenzo[b]furan 
• 119619-37-3 1-(benzofuran-2-yl)ethan-1-ol 
• 91703-34-3 2-(β,β-dibromovinyl)phenol 
• 13939-06-5 molybdenum hexacarbonyl 
• 41717-28-6 2-benzofuroyl chloride 

Downstream Products

• 78917-44-9 2-Benzofuranpropionic acid-β-oxo-ethylester 
• 55038-01-2 benzofuran-2-yl-methanol 
• 496-41-3 Benzofuran-2-carboxylic acid 
• 42974-19-6 benzo[b]furan-2-carbohydrazide 
• 1354349-58-8 methyl 3-(4-(methoxycarbonyl)phenyl)benzofuran-2-carboxylate 
• 938443-86-8 methyl 3-phenylbenzofuran-2-carboxylate 
• 41014-27-1 2-bromomethylbenzofuran 
• 5149-69-9 3-(1-benzofuran-2-yl)-3-oxopropanenitrile 

Relevant articles and documents

Remarkable Differences in Reactivity between Cyanide and N-Heterocyclic Carbenes in Ring-Closing Reactions of 4-(2-Formylphenoxy)but-2-Enoate Derivatives

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Cobalt Nanoparticles-Catalyzed Widely Applicable Successive C?C Bond Cleavage in Alcohols to Access Esters

Selective cleavage and functionalization of C?C bonds have important applications in organic synthesis and biomass utilization. However, functionalization of C?C bonds by controlled cleavage remains difficult and challenging because they are inert. Herein, we describe an unprecedented efficient protocol for the breaking of successive C?C bonds in alcohols to form esters with one or multiple carbon atoms less using heterogeneous cobalt nanoparticles as catalyst with dioxygen as the oxidant. A wide range of alcohols including inactive long-chain alkyl aryl alcohols undergo smoothly successive cleavage of adjacent ?(C?C)n? bonds to afford the corresponding esters. The catalyst was used for seven times without any decrease in activity. Characterization and control experiments disclose that cobalt nanoparticles are responsible for the successive cleavage of C?C bonds to achieve excellent catalytic activity, while the presence of Co-Nx has just the opposite effect. Preliminary mechanistic studies reveal that a tandem sequence reaction is involved in this process.

Direct Alkoxycarbonylation of Heteroarenes via Cu-Mediated Trichloromethylation and in Situ Alcoholysis

We report an efficient approach for direct alkoxycarbonylation of furans as well as other heteroarenes via a one-step copper-mediated reaction of three components (i.e., heteroarene, alcohol, and CHCl3). The copper additive was confirmed to simultaneously promote the reaction in three pathways: oxidant cracking, single electron transfer, and alcoholysis. By means of this protocol, various functionalized furancarboxylates and other heteroarenecarboxylates were facilely obtained in moderate to good yields.