16499-58-4

Basic information

• Product Name: 7-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE
• Synonyms: 7-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE;7-(trifluoroMethyl)quinazolin-4(1H)-one;7-(TrifluoroMethyl)quinazolin-4-ol
• CAS NO: 16499-58-4
• Molecular Formula: C₉H₅F₃N₂O
• Molecular Weight: 214.14
• Mol File: 16499-58-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 225-227 °C(Solv: ethanol (64-17-5))
• Boiling Point: 290.0±50.0 °C(Predicted)
• Appearance: /
• Density: 1.51±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.13±0.20(Predicted)
• CAS DataBase Reference: 7-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE(16499-58-4)
• EPA Substance Registry System: 7-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE(16499-58-4)

Safety Data

• Hazardous Substances Data: 16499-58-4(Hazardous Substances Data)

Usage

General Description

7-(trifluoromethyl)quinazolin-4(3H)-one is a chemical compound with the formula C9H5F3N2O. It is a heterocyclic compound containing a quinazolin-4(3H)-one core with a trifluoromethyl group attached to the 7th position. 7-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE has potential applications in medicinal chemistry and drug development due to its unique structure and potential biological activities. It can be used as a starting material in the synthesis of various pharmaceuticals and agrochemicals. The trifluoromethyl group in the molecule also imparts unique chemical and physical properties, making it of interest for further research and applications in various fields.

Upstream product

• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 77287-34-4 formamide 
• 67-56-1 methanol 
• 713-41-7 2-amino-4-(trifluoromethyl)benzamide 
• 64-18-6 formic acid 
• 778-94-9 2-nitro-4-trifluoromethyl-benzonitrile 

Downstream Products

• 16499-65-3 4-chloro-7-trifluoromethyl-quinazoline 
• 374556-29-3 N-[3-(1,2-dimethyl-1H-imidazol-5-yl)phenyl]-7-(trifluoromethyl)-4-quinazolinamine 
• 374556-30-6 N-[3-(4,5-dimethyl-1H-imidazol-1-yl)phenyl]-7-(trifluoromethyl)-4-quinazolinamine 
• 129190-40-5 2,6-bis(4'-benzylpiperidin-1'-ylmethyl)-4-(7''-trifluoromethylquinazolin-4''-ylamino)phenol 
• 129190-32-5 2,6-bis(dipentylaminomethyl)-4-(7'-trifluoromethylquinazolin-4'-ylamino)phenol 
• 129190-38-1 2,6-bis(3',5'-dimethylpiperidin-1'-ylmethyl)-4-(7''-trifluoromethylquinazolin-4''-ylamino)phenol 
• 129190-36-9 2,6-bis(3'-methylpiperidin-1'-ylmethyl)-4-(7''-trifluoromethylquinazolin-4''-ylamino)phenol 
• 129190-37-0 2,6-bis(4'-methylpiperidin-1'-ylmethyl)-4-(7''-trifluoromethylquinazolin-4''-ylamino)phenol 
• 129190-35-8 2,6-bis(piperidin-1'-ylmethyl)-4-(7''-trifluoromethylquinazolin-4''-ylamino)phenol 
• 129190-30-3 2,6-bis(dipropylaminomethyl)-4-(7'-trifluoromethylquinazolin-4'-ylamino)phenol 
• 129210-19-1 2,6-bis(pyrrolidin-1'-ylmethyl)-4-(7''-trifluoromethylquinazolin-4''-ylamino)phenol 
• 129190-34-7 2,6-bis(N-butyl-N-methylaminomethyl)-4-(7'-trifluoromethylquinazolin-4'-ylamino)phenol 
• 129190-29-0 2,6-bis(diethylaminomethyl)-4-(7'-trifluoromethylquinazolin-4'-ylamino)phenol 
• 129190-28-9 2,6-bis(dimethylaminomethyl)-4-(7'-trifluoromethylquinazolin-4'-ylamino)phenol 

Relevant articles and documents

Self-catalyzed phototandem perfluoroalkylation/cyclization of unactivated alkenes: Synthesis of perfluoroalkyl-substituted quinazolinones

A novel visible-light-induced radical tandem trifluoromethylation/cyclization of unactivated alkenes with sodium perfluoroalkanesulfinates (Rf = CF3, C3F7, C4F9, C6F13, C8F17) under air atmosphere has been developed. A range of quinazolinones containing unactivated alkene moiety and sodium perfluoroalkanesulfinates were compatible with this transformation, leading to a variety of perfluoroalkyl-substituted quinazoline alkaloids. Remarkably, the experiment can be carried out without any metal catalyst, strong oxidant, or external photosensitizer.

Photo-triggered self-catalyzed fluoroalkylation/cyclization of unactivated alkenes: Synthesis of quinazolinones containing the CF2R group

A novel photo-triggered self-catalyzed fluoroalkylation/cyclization of quinazolinones containing unactivated alkenes with various fluoroalkyl bromides has been developed. This transformation exhibits excellent substrate generality with respect to both the coupling partners. Of note is that this is the first example describing the Csp3-Br bond homolysis of alkyl bromides via a substrate (quinazolinones) induced energy transfer process. Additionally, the mild conditions, tolerance to a wide range of functional groups and operational simplicity make this protocol practical for the synthesis of fluorine-containing ring-fused quinazolinones. This journal is

HARMFUL ARTHROPOD CONTROL METHOD USING HETEROCYCLIC COMPOUND

PROBLEM TO BE SOLVED: To provide a method for controlling a harmful arthropod. SOLUTION: The compound shown by the formula (I) [in the formula, Q represents the group, etc. represented by the formula Q1, Z represents an oxygen atom, etc., A1 re