165108-07-6 Usage
Description
Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)is a complex organic compound with a unique structure that exhibits potent antiparasitic properties. It is a derivative of the naturally occurring macrocyclic lactone avermectins, which are produced by the soil-dwelling bacterium Streptomyces avermitilis. Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-.alpha.-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)has been modified to enhance its efficacy and stability, making it a valuable asset in the development of new antiparasitic agents and insecticides.
Uses
Used in Veterinary Medicine:
Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)is used as an antiparasitic agent in veterinary medicine for the treatment and prevention of various parasitic infections in animals. Its broad-spectrum activity against nematodes, arthropods, and protozoa makes it an effective tool for managing parasitic diseases in livestock and pets.
Used in the Preparation of New Antiparasitic Agents and Insecticides:
Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)is also used as a key component in the development of new antiparasitic agents and insecticides. Its unique structure and potent activity against a wide range of parasites and insects make it an attractive candidate for the creation of novel compounds with improved efficacy, safety, and environmental compatibility.
In the agricultural industry, Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)is used as an active ingredient in insecticides for the control of various pests that can cause significant damage to crops. Its ability to target a broad range of insects, including mites, ticks, and other arthropods, makes it a valuable tool for integrated pest management strategies.
In the pharmaceutical industry, Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)is used as a starting material for the synthesis of new antiparasitic drugs. Its unique chemical structure provides a foundation for the development of innovative compounds with improved pharmacological properties, such as increased potency, selectivity, and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 165108-07-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,1,0 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 165108-07:
(8*1)+(7*6)+(6*5)+(5*1)+(4*0)+(3*8)+(2*0)+(1*7)=116
116 % 10 = 6
So 165108-07-6 is a valid CAS Registry Number.
InChI:InChI=1/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35?,37?,38-,39-,40+,42+,43+/m0/s1
165108-07-6Relevant articles and documents
New Selamectin Intermediates, Preparation Method Thereof And Preparation Method For Selamectin Using The Same
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Paragraph 0058; 0097-0100, (2019/07/05)
The present invention relates to a novel intermediate of selamectin which is an antiparasitic drug, a manufacturing method thereof, and an improved method for manufacturing selamectin using the same. More particularly, the present invention relates to: the novel intermediate produced by a four-step synthesis process of a deglycosylation reaction, a hydrogenation reaction, an oxidation reaction, and an oximation reaction; and the improved method of selamectin using the same. The novel intermediate of selamectin according to the present invention has thermal and chemical stability and by using the novel method for manufacturing selamectin of the present invention, it is possible to manufacture selamectin having a higher synthesis yield and purity compared to existing technology.COPYRIGHT KIPO 2019
Preparation method of selamectin
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Paragraph 0053; 0054; 0055; 0072; 0073; 0074, (2017/09/18)
The invention provides an improved preparation technology of selamectin. The improved preparation technology comprises the following steps of (1) in the presence of a Wilson catalyst, reducing the selamectin DL by hydrogen, so as to obtain an intermediate SL1; (2) desugaring the intermediate SL1 obtained in step (1) by an organic solvent hydrochloric acid solution (by dissolving hydrochloric acid gas into an organic solvent), so as to obtain an intermediate SL2; (3) oxidizing the intermediate SL2 obtained in step (2) by manganese dioxide, so as to obtain an intermediate SL3; (4) oximating the intermediate SL3 obtained in step (3) by hydroxylamine hydrochloride, so as to obtain selamectin SL; (5) recrystallizing the crude product of selamectin SL obtained in step (4) by methylbenzene, acetone and methanol, so as to obtain the purified selamectin SL.
