165253-31-6Relevant articles and documents
Chemoselective and Tandem Reduction of Arenes Using a Metal–Organic Framework-Supported Single-Site Cobalt Catalyst
Akhtar, Naved,Begum, Wahida,Chauhan, Manav,Manna, Kuntal,Newar, Rajashree,Rawat, Manhar Singh
supporting information, (2022/01/19)
The development of heterogeneous, chemoselective, and tandem catalytic systems using abundant metals is vital for the sustainable synthesis of fine and commodity chemicals. We report a robust and recyclable single-site cobalt-hydride catalyst based on a porous aluminum metal–organic framework (DUT-5 MOF) for chemoselective hydrogenation of arenes. The DUT-5 node-supported cobalt(II) hydride (DUT-5-CoH) is a versatile solid catalyst for chemoselective hydrogenation of a range of nonpolar and polar arenes, including heteroarenes such as pyridines, quinolines, isoquinolines, indoles, and furans to afford cycloalkanes and saturated heterocycles in excellent yields. DUT-5-CoH exhibited excellent functional group tolerance and could be reusable at least five times without decreased activity. The same MOF-Co catalyst was also efficient for tandem hydrogenation–hydrodeoxygenation of aryl carbonyl compounds, including biomass-derived platform molecules such as furfural and hydroxymethylfurfural to cycloalkanes. In the case of hydrogenation of cumene, our spectroscopic, kinetic, and density functional theory (DFT) studies suggest the insertion of a trisubstituted alkene intermediate into the Co–H bond occurring in the turnover limiting step. Our work highlights the potential of MOF-supported single-site base–metal catalysts for sustainable and environment-friendly industrial production of chemicals and biofuels.
Lewis Acid Catalyzed Electrophilic Aminomethyloxygenative Cyclization of Alkynols with N, O-Aminals
Chen, Anrong,Yu, Houjian,Yan, Jiaqi,Huang, Hanmin
supporting information, p. 755 - 759 (2020/01/28)
Lewis acid enables the electrophilic carbooxygenative cyclization of alkynols with N,O-aminals. The new process proceeds efficiently under very mild conditions via a pathway that is opposite to classical carbo-metalation. These reactions exhibit broad substrate generality and functional group compatibility, leading to a wide variety of 5-8-membered oxacycles bearing diverse functional groups. The cyclization products can be elaborated via simple functional group transformations to generate synthetically useful oxacycles.
3-aminomethyl tetrahydrofuran preparation method
-
Paragraph 0060-0068, (2020/01/12)
The invention provides a 3-aminomethyl tetrahydrofuran preparation method, which comprises: carrying out a condensation reaction by using tetrahydrofuran-3-one and nitromethane as raw materials to obtain 3-nitromethylene tetrahydrofuran, and carrying out catalytic hydrogenation reduction to obtain 3-aminomethyl tetrahydrofuran. According to the invention, the method has advantages of cheap and easily available raw materials, good stability, low cost, simple preparation steps, safe and simple operation, easy reaction achieving, little wastewater generation, environmental protection, few side reactions, high reaction selectivity, good atom economy, high product purity and high yield, and is suitable for industrial production.