166383-33-1

Basic information

• Product Name: 1-[(2S,3S)-3-(N₂-Quinoxalin-2-ylmethyl-L-asparaginyl)-amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide
• Synonyms: 1-[(2S,3S)-3-(N₂-Quinoxalin-2-ylmethyl-L-asparaginyl)-amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide
• CAS NO: 166383-33-1
• Molecular Weight: 603.721
• Mol File: 166383-33-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[(2S,3S)-3-(N₂-Quinoxalin-2-ylmethyl-L-asparaginyl)-amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2S,3S)-3-(N₂-Quinoxalin-2-ylmethyl-L-asparaginyl)-amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide(166383-33-1)
• EPA Substance Registry System: 1-[(2S,3S)-3-(N₂-Quinoxalin-2-ylmethyl-L-asparaginyl)-amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide(166383-33-1)

Safety Data

• Hazardous Substances Data: 166383-33-1(Hazardous Substances Data)

Upstream product

• 1593-08-4 Quinoxaline-2-carboxaldehyde 

Relevant articles and documents

Inhibitors of HIV protease

Compounds of formula (I): STR1 wherein: R1 is hydrogen, alkyl, aralkyl, --CORa, --CORb, --CSRa, --CSRb, --SO2 Rb, --CONHRb, --CSNHRb, --CONRb Rb or --CSNRb Rb ; R2 is hydrogen or alkyl; R3 is hydrogen, alkylidene, substituted alkyl, or Rb ; R4 is optionally substituted alkyl, cycloalkyl, or aryl; R5 is Rb O--, Rb Rb N--, Rb HN--, aralkyloxycarbonyloxy or aralkyloxycarbonylamino, or R5 is --(CH2)p --D--(CH2)r --, where D is a single bond, carbonyl, oxygen, sulfur, --NH--, --(CH2 =CH2)-- or --NHCO--; and p and r are each 0 or an integer from 1 to 5; A is --(CH2)m --B--(CH2)n -- where B is a single bond, carbonyl, oxygen, sulfur, --NH--, --(CH2 =CH2)-- or --NHCO--; and m and n are each 0 or an integer from 1 to 5; Ra is alkoxy, aralkyloxy, aryloxy or alkoxycarbonyl; Rb is optionally substituted alkyl, cycloalkyl, heterocyclic, aryl or arylalkenyl; and pharmaceutically acceptable salts and esters thereof and pro-drugs therefor, have the ability to inhibit the activity of HIV protease and may thus be used for the treatment and prophylaxis of AIDS.