16742-78-2Relevant articles and documents
Exploration of imidazole and imidazopyridine dimers as anticancer agents: Design, synthesis, and structure–activity relationship study
Meenakshisundaram, Sangeetha,Manickam, Manoj,Pillaiyar, Thanigaimalai
, (2019/11/03)
Dimerization of proteins/receptors plays a critical role in various cellular processes, including cell proliferation and differentiation. Therefore, targeting such dimeric proteins/receptors by dimeric small molecules could be a potential therapeutic appr
Parallel Recognition by Kinetic Control with Imino Aldehyde Substrates that are Prone to Redistribution
Orita, Akihiro,Nagano, Yoshifumi,Nakazawa, Koichi,Otera, Junzo
, p. 548 - 555 (2007/10/03)
One-shot treatment of a mixture of Danishefsky diene 4 and tetraallyltin 8 with 3-formylbenzylidene imines 1 in the presence of Sc(OTf)3 catalyst provides a single product 13 as a result of exclusive Diels-Alder and allylation reactions on the imine and aldehyde functions, respectively. The chemoselectivities of the respective elementary reactions are improved in the parallel reaction, and the redistribution of substrate 1 that is induced readily by Sc(OTf)3 is completely suppressed, thus offering a novel protocol for simplification of the multi-step chemical process.