167993-12-6

Basic information

• Product Name: 5-AMINO-DI-T-BUTYL ISOPHTHALATE
• Synonyms: 5-AMINO-DI-T-BUTYL ISOPHTHALATE;5-AMINO-DI-T-BUTYL ISOPHATHALATE;Di-tert-Butyl 5-aMinoisophthalate
• CAS NO: 167993-12-6
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.35812
• Mol File: 167993-12-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-AMINO-DI-T-BUTYL ISOPHTHALATE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-DI-T-BUTYL ISOPHTHALATE(167993-12-6)
• EPA Substance Registry System: 5-AMINO-DI-T-BUTYL ISOPHTHALATE(167993-12-6)

Safety Data

• Hazardous Substances Data: 167993-12-6(Hazardous Substances Data)

Upstream product

• 13438-30-7 5-nitro-1,3-benzenedicarbonylchloride 
• 618-88-2 5-nitrobenzene-1,3-dicarboxylic acid 
• 99-31-0 5-aminoisophthalic acid 

Downstream Products

• 1378942-75-6 tetra-tert-butyl 5,5'-(carbonylbis(azanediyl))diisophthalate 
• 1334547-47-5 5,5′,5″-(4,4′,4″-(benzene-1,3,5-triyl)tris(1H-1,2,3-triazole-4,1-diyl))-triisophthalic acid 
• 167992-83-8 N-(9-fluorenylmethoxycarbonyl)-1S-(3,5-di-t-butyloxycarbonylphenylaminocarbonyl)-2-(4-iodophenyl)ethylamine 

Relevant articles and documents

SYNTHETIC PROCESSES AND INTERMEDIATES

The invention provides synthetic processes and synthetic intermediate compounds that can be used to prepare therapeutic conjugates. The invention also provides methods for treating HBV and/or HDV infection in a human by administering a therapeutic conjugate prepared by the synthetic methods of the invention.

Urea metal-organic frameworks as effective and size-selective hydrogen-bond catalysts

A new urea-containing metal-organic framework (MOF) was synthesized to act as a heterogeneous catalyst. Ureas are well-known for self-recognition and aggregation behavior, resulting in loss of catalytic competency. The catalyst spatial isolation achievable in a porous MOF environment suggests a potentially general solution. The combination of a symmetrical urea tetracarboxylate strut, 4,4′-bipyridine, and Zn(NO3)2?6H2O under solvothermal conditions afforded a new microporous MOF (NU-601). This material is indeed an effective hydrogen-bond-donor catalyst for Friedel-Crafts reactions between pyrroles and nitroalkenes, whereas a homogeneous urea is much less competent. The higher rates of reaction of small substrates relative to larger ones with NU-601 strongly suggest that catalysis primarily occurs within the pores of this new material rather than on its exterior. To the best of our knowledge, this approach is the first example of specific engineering of successful hydrogen-bonding catalysis into a MOF material.

Catalytic antibody regulated prodrug therapy

Catalytic antibodies capable of catalysing activation of a carbamate (-O-CO-NH-) containing prodrug suitable for Antibody Directed Abzyme Prodrug Therapy (ADAPT) by catalysing breakdown of the prodrug at the carbamate position by a non-spontaneous reaction mechanism. The non-spontaneous reaction preferably has a BAc2 mechanism and the prodrug is a preferably a nitrogen mustard aryl carbamate. The invention also includes relevant immunogens, screens for catalytic activity using short transition state analogues and ADAPT systems.