169222-42-8 Usage
Description
4-(Trifluoromethoxy)phenylmagnesium bromide is an organometallic reagent that consists of a magnesium atom bonded to a bromide ion and a 4-(trifluoromethoxy)phenyl group. It is a versatile intermediate in organic synthesis, particularly for the preparation of various pharmaceutical compounds and organic molecules.
Uses
Used in Pharmaceutical Industry:
4-(Trifluoromethoxy)phenylmagnesium bromide is used as a reactant for the preparation of chromanol derivatives, which are a novel class of cholesteryl ester transfer protein (CETP) inhibitors. These inhibitors are used for the treatment of cardiovascular diseases, as they help in modulating the levels of cholesterol in the body.
Used in Organic Synthesis:
4-(Trifluoromethoxy)phenylmagnesium bromide is used as a reactant in Pd-catalyzed cross-coupling reactions, which are widely employed in the synthesis of complex organic molecules and pharmaceutical compounds. This reagent allows for the formation of carbon-carbon or carbon-heteroatom bonds, enabling the construction of diverse molecular structures.
Used in Medicinal Chemistry:
4-(Trifluoromethoxy)phenylmagnesium bromide is used as a reactant for the preparation of indazole-pyridine derivatives, which are protein kinase B/Akt inhibitors. These inhibitors have potential applications in the treatment of various diseases, including cancer, by modulating the activity of the Akt signaling pathway. The use of this reagent in the synthesis process helps in reducing hypotension, a common side effect associated with some protein kinase inhibitors.
Check Digit Verification of cas no
The CAS Registry Mumber 169222-42-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,2,2 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 169222-42:
(8*1)+(7*6)+(6*9)+(5*2)+(4*2)+(3*2)+(2*4)+(1*2)=138
138 % 10 = 8
So 169222-42-8 is a valid CAS Registry Number.
169222-42-8Relevant articles and documents
Cobalt-Catalyzed Electrophilic Amination of Aryl- and Heteroarylzinc Pivalates with N-Hydroxylamine Benzoates
Chen, Yi-Hung,Gra?l, Simon,Knochel, Paul
supporting information, p. 1108 - 1111 (2018/01/01)
Aryl- and heteroarylzinc pivalates can be aminated with O-benzoylhydroxylamines at 25 °C within 2–4 h in the presence of 2.5–5.0 % CoCl2?2 LiCl to furnish the corresponding tertiary arylated or heteroarylated amines in good yields. This electrophilic amination also provides access to diarylamines and aryl(heteroaryl)amines. A new tuberculosis drug candidate (Q203) was prepared in six steps and 56 % overall yield by using this cobalt-catalyzed amination as the key step.
C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF
-
Paragraph 0151, (2013/06/04)
C-aryl glucoside derivatives, preparation processes and pharmaceutical uses thereof are disclosed. In particular, C-aryl glucoside derivatives represented by formula (I), with each substituent defined in the application, pharmaceutically acceptable salts or stereoisomers thereof, their preparation methods, and pharmaceutical compositions containing the derivatives as well as their uses as therapeutic agents, particularly as sodium-dependent glucose cotransporter (SGLT)-1 inhibitors, are disclosed.
