16955-22-9Relevant articles and documents
Method for preparing deuterated compound through decarboxylation and deuteration of carboxylic acid
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Paragraph 0088; 0090-0091, (2021/06/13)
The invention relates to a method for preparing a deuterated compound through decarboxylation and deuteration of carboxylic acid. According to the method, a carboxylic acid compound is used as a raw material, hydrogen atoms of carboxylate radicals are exc
Method for deuterating organic matter
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Page/Page column 5; 8, (2019/10/01)
The present invention relates to a method of deuterating an organic matter, especially relates to a method of deuterating an organic compound containing a mercapto group or a disulfide bond, and belongs to the technical field of molecular marking. The method of deuterating the organic matter the following steps: dissolving the organic matter in a mixed solvent of an organic solvent and deuterium oxide, adding a phosphine reagent and a free radical initiator, and carrying out a reaction under a light condition for 3-6 h to convert the substrate into a corresponding deuterated product, wherein the organic matter is a thiol, a disulfide or a cysteine-containing polypeptide organic compound. The deuterating method has the characteristics of high deuteration efficiency, good selectivity, good functional group tolerance, high yield, mild reaction conditions, no metals participating in the reaction, wide substrate range and the like, is especially suitable for selectively deuterating the specific position of the carbon chain, and is also suitable for polypeptide substrates.