169557-51-1

Basic information

• Product Name: Acetic acid (1S,2S)-2-benzoylamino-1-phenyl-propyl ester
• Synonyms: Acetic acid (1S,2S)-2-benzoylamino-1-phenyl-propyl ester
• CAS NO: 169557-51-1
• Molecular Weight: 297.354
• Mol File: 169557-51-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid (1S,2S)-2-benzoylamino-1-phenyl-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (1S,2S)-2-benzoylamino-1-phenyl-propyl ester(169557-51-1)
• EPA Substance Registry System: Acetic acid (1S,2S)-2-benzoylamino-1-phenyl-propyl ester(169557-51-1)

Safety Data

• Hazardous Substances Data: 169557-51-1(Hazardous Substances Data)

Upstream product

• 134522-09-1 N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-benzamide; N-benzoyl-(+)-norpseudoephedrine 
• 108-24-7 acetic anhydride 
• 85-44-9 phthalic anhydride 
• 28143-91-1 (1S,2S)-2-amino-1-phenyl-1,3-diol 
• 123537-84-8 (1S,2S)-1-phenyl-2-phthalimido-propane-1,3-diol 
• 176538-75-3 Benzoic acid (1S,2S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-phenyl-propyl ester 
• 176538-73-1 Benzoic acid (1S,2R)-3-bromo-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-phenyl-propyl ester 

Downstream Products

• 61347-73-7 (1S,2S)-2-(benzylamino)-1-phenyl-1-propanol 
• 159099-80-6 (1S,2S)-2-(N-benzyl-N-methylamino)-1-phenyl-1-propanol 
• 90-82-4 pseudoephedrine 

Relevant articles and documents

(1S,2S)-2-Amino-1-phenyl-1,3-propanediol, a spin off from chloramphenicol manufacture, as chiral synthon for (1S, 2S)-pseudoephedrine and (R)-phenylalaninol

(1S,2S)-2-Amino-1-phenyl-1,3-propanediol (3a), a discarded optically active material in one of the processes for the manufacture of chloramphenicol, has been transformed into (S,S)-pseudoephedrine (4) and (R)-phenylalaninol (5). The opposite selectivity of highly regioselective oxidative ring opening of the benzaldehyde acetal of (1S,2S)-2-phthalimido-1-phenyl-1,3-propanediol by NBS and highly regioselective ring opening of the cyclic sulphite of the same substrate by LiBr are the key steps in the transformations respectively.