17064-77-6

Basic information

• Product Name: N-(2-nitrobenzylidene)aniline
• Synonyms: N-(2-nitrobenzylidene)aniline;2-Nitro-N-phenylbenzenemethanimine;N-Phenyl-2-nitrobenzenemethanimine;N-Phenyl-2-nitrobenzylideneamine
• CAS NO: 17064-77-6
• Molecular Formula: C₁₃H₁₀N₂O₂
• Molecular Weight: 226.2307
• EINECS: 241-126-8
• Mol File: 17064-77-6.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 383.4°Cat760mmHg
• Flash Point: 185.7°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 9.75E-06mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: N-(2-nitrobenzylidene)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-nitrobenzylidene)aniline(17064-77-6)
• EPA Substance Registry System: N-(2-nitrobenzylidene)aniline(17064-77-6)

Safety Data

• Hazardous Substances Data: 17064-77-6(Hazardous Substances Data)

Usage

Description

N-(2-nitrobenzylidene)aniline, with the molecular formula C13H10N2O2, is a yellow solid chemical compound. It is primarily recognized for its role as a pH indicator and its contribution to the production of dyes and pigments. Additionally, it is utilized in the synthesis of other organic compounds, including azo dyes and pharmaceuticals. Due to its potential health risks such as skin and eye irritation and possible carcinogenic effects, it is categorized as a hazardous compound that requires careful handling and proper safety precautions.

Uses

Used in Chemical Synthesis:
N-(2-nitrobenzylidene)aniline is used as a precursor in the synthesis of various organic compounds, including azo dyes and pharmaceuticals, for its ability to undergo specific chemical reactions that facilitate the creation of these products.
Used as a pH Indicator:
In the field of chemistry and biology, N-(2-nitrobenzylidene)aniline serves as a pH indicator, leveraging its color-changing properties in response to different pH levels to measure and monitor acidity or alkalinity in solutions.
Used in Dye and Pigment Production:
N-(2-nitrobenzylidene)aniline is employed as a key component in the production of dyes and pigments, where its color characteristics are utilized to create a range of hues for various applications in industries such as textiles, paints, and plastics.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, N-(2-nitrobenzylidene)aniline is used in the synthesis of certain pharmaceuticals, contributing to the development of new drugs and medicinal compounds.
Safety Precautions:
When handling N-(2-nitrobenzylidene)aniline, it is crucial to adhere to proper safety measures due to its hazardous nature. This includes the use of personal protective equipment to prevent skin and eye contact, as well as implementing handling procedures that minimize exposure and potential health risks.

InChI:InChI=1/C13H10N2O2/c16-15(17)13-9-5-4-6-11(13)10-14-12-7-2-1-3-8-12/h1-10H/b14-10+

Upstream product

• 62-53-3 aniline 
• 552-89-6 2-nitro-benzaldehyde 
• 612-25-9 2-Nitrobenzyl alcohol 
• 17064-86-7 N-(2-nitrobenzylidene)-4-nitroaniline 

Downstream Products

• 20887-06-3 N-(2-aminobenzyl)aniline 
• 27126-08-5 2-nitroso-benzoic acid anilide 
• 3682-71-1 2-phenyl-2H-indazole 
• 58809-90-8 4-methyl-N'-(2-nitrobenzylidene)-benzenesulfonohydrazide 
• 271-58-9 anthranil 
• 109772-94-3 3-cyano-2-phenyl-2H-indazole 1-oxide 
• 861326-09-2 sulfurous acid mono-(1-oxy-2-phenyl-2H-indazol-3-yl ester) 
• 17049-65-9 2-phenyl-1,2-dihydro-3H-indazol-3-one 
• 1204524-86-6 C₂₈H₂₂N₄O₂ 
• 119091-74-6 2-nitrophenyl-(bis-3-indolyl)methane 
• 109772-87-4 2-(2-nitrophenyl)-2-phenylaminoacetonitrile 
• 52197-49-6 2-(9b-methyl-(3ar,9bc)-2,3,3a,4,5,9b-hexahydro-furo[3,2-c]quinolin-4t-yl)-aniline 
• 75063-89-7 3-Phenyl-3,4-dihydro-quinazolin-2-ylamine 
• 94-69-9 2'-methylformanilide 

Relevant articles and documents

Design, synthesis and anticandidal evaluation of indazole and pyrazole derivatives

Candidiasis, caused by yeasts of the genus Candida, is the second cause of superficial and mucosal infections and the fourth cause of bloodstream infections. Although some antifungal drugs to treat candidiasis are available, resistant strains to current therapies are emerging. Therefore, the search for new candicidal compounds is certainly a priority. In this regard, a series of indazole and pyrazole derivatives were designed in this work, employing bioisosteric replacement, homologa-tion, and molecular simplification as new anticandidal agents. Compounds were synthesized and evaluated against C. albicans, C. glabrata, and C. tropicalis strains. The series of 3-phenyl-1H-indazole moiety (10a–i) demonstrated to have the best broad anticandidal activity. Particularly, compound 10g, with N,N-diethylcarboxamide substituent, was the most active against C. albicans and both miconazole susceptible and resistant C. glabrata species. Therefore, the 3-phenyl-1H-indazole scaf-fold represents an opportunity for the development of new anticandidal agents with a new chemo-type.

Cysteine fluorescent probe and preparation method and application thereof

The invention discloses a cysteine fluorescent probe and a preparation method and application thereof. The cysteine fluorescent probe comprises quinolinium ions serving as a framework, trimethylsilyl bonded with the quinolinium ion skeleton structure through a carbon-silicon single bond, and a p-phenyl acrylate group and counter ions which are connected with the quinolinium ion skeleton structure through a carbon-carbon single bond. The fluorescence intensity of the cysteine fluorescent probe is almost completely quenched when cysteine is added, the fluorescence intensity of the cysteine fluorescent probe and the concentration of cysteine are correspondingly reduced according to a linear relation, and the cysteine fluorescent probe has high selectivity on cysteine, can distinguish cysteine from three biological mercaptans, and is suitable for being widely applied to detection of cysteine in living cells.

Functional POM-catalyst for selective oxidative dehydrogenative couplings under aerobic conditions

Development of selective and efficient reusable catalytic systems for sustainable chemical production under benign conditions is attractive and received much attention. Herein, we report a rod-shaped octadecyl trimethylammonium functionalized Keggin-type polyoxometalate [PMO12O40] hybrids (OTA-POM) as an efficient heterogeneous catalyst for selective oxidative dehydrogenative couplings under aerobic conditions without any additive or external base. The catalyst recovery and subsequent five successive recyclability studies of hybrid POM confirms the heterogeneous nature of present catalytic system.