1709-59-7

Basic information

• Product Name: 4-AMINO-N,N-DIMETHYL-BENZENESULFONAMIDE
• Synonyms: AKOS BBS-00000284;AKOS BBB/031;4-AMINO-N,N-DIMETHYL-BENZENESULFONAMIDE;BUTTPARK 34\07-94;IFLAB-BB F1591-0314;OTAVA-BB BB7216850059;4-amino-n,n-dimethyl-benzenesulfonamid;4-amino-N,N-dimethylbenzenesulphonamide
• CAS NO: 1709-59-7
• Molecular Formula: C₈H₁₂N₂O₂S
• Molecular Weight: 200.26
• EINECS: 216-970-5
• Mol File: 1709-59-7.mol
• Article Data: 18

Chemical Properties

• Melting Point: 170-172°C
• Boiling Point: 352.9°Cat760mmHg
• Flash Point: 167.2°C
• Appearance: /
• Density: 1.2581 (rough estimate)
• Vapor Pressure: 3.72E-05mmHg at 25°C
• Refractive Index: 1.5690 (estimate)
• Storage Temp.: 2-8°C(protect from light)
• PKA: pKa 2.11(H2O t = 25 I = 0.05) (Uncertain)
• Water Solubility: 626.8mg/L(37 oC)
• CAS DataBase Reference: 4-AMINO-N,N-DIMETHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-N,N-DIMETHYL-BENZENESULFONAMIDE(1709-59-7)
• EPA Substance Registry System: 4-AMINO-N,N-DIMETHYL-BENZENESULFONAMIDE(1709-59-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-22
• Safety Statements: 26-36/37/39-36/37
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 1709-59-7(Hazardous Substances Data)

Usage

Uses

N,N-Dimethyl 4-aminobenzenesulfonamide

InChI:InChI=1/C8H12N2O2S/c1-10(2)13(11,12)8-5-3-7(9)4-6-8/h3-6H,9H2,1-2H3

Upstream product

• 54951-54-1 N-[4-(dimethylamino-4-ylsulfonyl)phenyl]acetamide 
• 7463-22-1 N,N-Dimethyl-p-chlorobenzenesulfonamide 
• 103-84-4 Acetanilid 
• 13360-57-1 dimethylamino sulfonyl chloride 
• 17459-03-9 4-(N,N-dimethylaminosulfonyl)nitrobenzene 
• 60-35-5 acetamide 
• 77767-94-3 (4,6-dimethylpyrimid-2′-yl)-trimethylammonium chloride 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 63-74-1 sulfanilamide 
• 77-78-1 dimethyl sulfate 
• 1709-52-0 N-methyl-4-aminobenzenesulfonamide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 124-40-3 dimethyl amine 
• 62-53-3 aniline 

Downstream Products

• 20805-57-6 4-isocyanato-benzenesulfonic acid dimethylamide 
• 17901-13-2 2-Amino-benzthiazol-6-sulfonsaeure-dimethylamid 
• 7463-22-1 N,N-Dimethyl-p-chlorobenzenesulfonamide 
• 41466-78-8 4-(N,N-Dimethylsulfamoyl)phenylhydrazine 
• 116929-35-2 N-(4-dimethylsulfamoyl-phenyl)-N'-methyl-thiourea 
• 93345-14-3 N-(N-acetyl-sulfanilyl)-sulfanilic acid dimethylamide 
• 100318-60-3 N-allyl-N'-(4-dimethylsulfamoyl-phenyl)-thiourea 
• 853725-76-5 N-(4-cyano-benzenesulfonyl)-sulfanilic acid dimethylamide 
• 33021-71-5 N-<2-Chlor-aethyl>-N'-<4-(dimethylsulfamoyl)-phenyl>-harnstoff 
• 69949-86-6 4-(6-methanesulfinyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]thiadiazol-3-ylideneamino)-N,N-dimethyl-benzenesulfonamide 
• 57946-84-6 N,N-Dimethyl-4-trifluoromethanesulfonylamino-benzenesulfonamide 
• 116691-43-1 4-(8-Hydroxy-quinolin-5-ylazo)-N,N-dimethyl-benzenesulfonamide 
• 98786-85-7 6-dodecyl-6-<2-hydroxy-5-<(4-(N,N-dimethylsulfamoyl)phenyl)azo>benzyl>-1,4,8,11-tetraoxacyclotetradecane 

Relevant articles and documents

Effect of photodynamic antibacterial chemotherapy combined with antibiotics on Gram-positive and gram-negative bacteria

The well-known and rapidly growing phenomenon of bacterial resistance to antibiotics is caused by uncontrolled, excessive and inappropriate use of antibiotics. One of alternatives to antibiotics is Photodynamic Antibacterial Chemotherapy (PACT). In the present study, the effect of PACT using a photosensitizer Rose Bengal alone and in combination with antibiotics including methicillin and derivatives of sulfanilamide synthesized by us was tested against antibiotic-sensitive and antibiotic-resistant clinical isolates of Gram-positive S. aureus and Gram-negative P. aeruginosa. Antibiotic-sensitive and resistant strains of P. aeruginosa were eradicated by Rose Bengal under illumination and by sulfanilamide but were not inhibited by new sulfanilamide derivatives. No increase in sensitivity of P. aeruginosa cells to sulfanilamide was observed upon a combination of Rose Bengal and sulfanilamide under illumination. All tested S. aureus strains (MSSA and MRSA) were effectively inhibited by PACT. When treated with sub-MIC concentrations of Rose Bengal under illumination, the minimum inhibitory concentrations (MIC) of methicillin decreased significantly for MSSA and MRSA strains. In some cases, antibiotic sensitivity of resistant strains can be restored by combining antibiotics with PACT.

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors

Novel 2-chloro-4-anilino-quinazolines designed as EGFR and VEGFR-2 dual inhibitors were synthesized and evaluated for inhibitory effects. EGFR and VEGFR-2 are validated targets in cancer therapy and combined inhibition might be synergistic for both antitumor activity and resistance prevention. The biological data obtained proved the potential of 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors, highlighting compound 8o, which was approximately 7-fold more potent on VEGFR-2 and approximately 11-fold more potent on EGFR compared to the prototype 7. SAR and docking studies allowed the identification of pharmacophoric groups for both kinases and demonstrated the importance of a hydrogen bond donor at the para position of the aniline moiety for interaction with conserved Glu and Asp amino acids in EGFR and VEGFR-2 binding sites.

PYRIMIDINE COMPOUNDS AS TUBERCULOSIS INHIBITORS

The present invention relates to compounds II useful as inhibitors of treating tuberculosis. The invention also provides processes for preparing compounds of the invention.