171018-17-0

Basic information

• Product Name: Tedizolid Impurity 39
• Synonyms: Tedizolid Impurity 39;Tedizolid Impurity K;Tedizolidted Impurity K
• CAS NO: 171018-17-0
• Molecular Formula: C₇H₇N₅
• Molecular Weight: 161.16
• Mol File: 171018-17-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 349.7±34.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 0.89±0.10(Predicted)
• CAS DataBase Reference: Tedizolid Impurity 39(CAS DataBase Reference)
• NIST Chemistry Reference: Tedizolid Impurity 39(171018-17-0)
• EPA Substance Registry System: Tedizolid Impurity 39(171018-17-0)

Safety Data

• Hazardous Substances Data: 171018-17-0(Hazardous Substances Data)

Usage

General Description

Tedizolid Impurity 39 is a potential impurity in the drug tedizolid, which is an antibiotic used to treat bacterial infections. The chemical structure of Tedizolid Impurity 39 appears to be closely related to the structure of tedizolid itself, and it is important to monitor and control its levels in the final drug product to ensure the safety and efficacy of tedizolid. Additionally, the presence of impurities can affect the stability, bioavailability, and overall quality of the drug. Therefore, Tedizolid Impurity 39 requires thorough characterization and quantification to ensure compliance with regulatory guidelines and to guarantee the safety and effectiveness of tedizolid.

Upstream product

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Relevant articles and documents

Antibacterial activity of a new class of tris homoleptic Ru (II)-complexes with alkyl-tetrazoles as diimine-type ligands

Herein, we describe a new family of tris chelate homoleptic Ru (II) complexes, [Ru(N^N)3]2+, where the role of the diimine-type ligands (N^N) was fulfilled by 2-pyridyl (PTZ) or 2-quinolyl tetrazole (QTZ) derivatives decorated with various alkyl substituents at the N-2 position of the tetrazole ring. The new Ru (II) complexes with general formula [Ru (PTZ-R)3]2+ and [Ru (QTZ-R)3]2+, were obtained as mixtures of facial (fac) and meridional (mer) isomers, as suggested by NMR (1H, 13C) experiments, and confirmed in the case of mer-[Ru (QTZ-Me)3]2+, by X-ray crystallography. The photophysical behavior of the tetrazole-based [Ru(N^N)3]2+ type species was investigated by UV–vis absorption spectroscopy, providing trends typical of polypyridyl Ru (II) complexes. The new homoleptic complexes fac/mer-[Ru (PTZ-R)3]2+ and fac/mer-[Ru (QTZ-R)3]2+ have been assessed for any eventual antimicrobial activity towards two different bacteria such as Gram-negative Escherichia coli and Gram-positive Deinococcus radiodurans. Whereas being inactive toward E. coli, the response of agar disks diffusion tests suggested that some of the new fac/mer Ru (II) complexes could inhibit the growth of D. radiodurans. This effect was further investigated by determining the growth kinetics in liquid medium of D. radiodurans exposed to the fac/mer-[Ru (PTZ-R)3]2+ and fac/mer-[Ru (QTZ-R)3]2+ complexes at different concentrations. The outcome of these experiments highlighted that the turn-on of the growth inhibitory effect took place as the linear hexyl chain was appended to the PTZ or QTZ scaffold, suggesting also how the inhibitory activity appeared more pronouncedly exerted by the facial isomers fac-[Ru (PTZ-Hex)3]2+ and fac-[Ru (QTZ-Hex)3]2+ (MIC = ca. 3.0 μg/ml) with respect to the corresponding meridional isomers (MIC = ca. 6.0 μg/ml).

Thermally Activated Delayed Fluorescence in CuI Complexes Originating from Restricted Molecular Vibrations

The mechanism of thermally activated delayed fluorescence (TADF) in molecules in aggregated or condensed solid states has been rarely studied and is not well understood. Nevertheless, many applications of TADF emitters are strongly affected by their lumin